Abstract Changes in cellular gene expression in response to small-molecule or genetic
perturbations have yielded signatures that can connect unknown mechanisms of action (MoA) to …

Identifying genetic alterations that prime a cancer cell to respond to a particular therapeutic
agent can facilitate the development of precision cancer medicines. Cancer cell-line (CCL) …

Background Almost all land plants develop tip-growing filamentous cells at the interface
between the plant and substrate (the soil). Root hairs form on the surface of roots of sporophytes …

To discover mechanisms that controlled the growth of the rooting system in the earliest land
plants, we identified genes that control the development of rhizoids in the liverwort …

Patients with sickle cell disease ( SCD ) experience a disproportionately high use of health
care resources. Several studies have examined depression and other negative mood states …

The colonization of the land by plants, sometime before 470 million years ago, was accompanied
by the evolution tissue systems [1–3]. Specialized structures with diverse functions—…

Having a sense of direction is a fundamental cellular trait that can determine cell shape,
division orientation, or function, and ultimately the formation of a functional, multicellular body. …

10.7554/eLife.43923.001 Reef-building corals depend on intracellular dinoflagellate symbionts
that provide nutrients. Besides sugars, the transfer of sterols is essential for corals and …

Land plant shoot structures evolved a diversity of lateral organs as morphological adaptations
to the terrestrial environment, with lateral organs arising independently in different …

Reef-building corals depend on an intracellular symbiosis with photosynthetic dinoflagellates
for their survival in nutrient-poor oceans. Symbionts are phagocytosed by coral larvae from …