Listeria monocytogenes has emerged as a remarkably tractable pathogen to dissect basic
aspects of cell biology, intracellular pathogenesis, and innate and acquired immunity. In order …

Listeria monocytogenes is a facultative intracellular pathogen that induces a cytosolic signaling
cascade resulting in expression of interferon (IFN)-β. Although type I IFNs are critical in …

The Listeria monocytogenes ActA protein mediates actin-based motility by recruiting and
stimulating the Arp2/3 complex. In vitro, the actin monomer-binding region of ActA is critical for …

Macrophages are permissive hosts to intracellular pathogens, but upon activation become
microbiocidal effectors of innate and cell-mediated immunity. How the fate of internalized …

The recent and dramatic rise of antibiotic resistance among bacterial pathogens underlies
the fear that standard treatments for infectious disease will soon be largely ineffective. …

Specialized protein translocation systems are used by many bacterial pathogens to deliver
effector proteins into host cells that interfere with normal cellular functions. How the host …

Type III secretion systems (T3SS) are essential for virulence in dozens of pathogens, but are
not required for growth outside the host. Therefore, the T3SS of many bacterial species are …

We developed a competitive index assay for murine listeriosis that tests the virulence of Listeria
monocytogenes strains in different organs and at various times postinoculation. Studies …

The Listeria monocytogenes surface protein ActA mediates actin‐based motility by interacting
with a number of host cytoskeletal components, including Ena/VASP family proteins, which …

Many Gram-negative pathogens express a type III secretion (T3SS) system to enable growth
and survival within a host. The three human-pathogenic Yersinia species, Y. pestis , Y. …