Background Understanding the genetic basis of airflow obstruction and smoking behaviour
is key to determining the pathophysiology of chronic obstructive pulmonary disease (COPD). …

Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide 1 .
We performed a genetic association study in 15,256 cases and 47,936 controls, with …

Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive
pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of …

Chronic obstructive pulmonary disease (COPD) is characterized by reduced lung function
and is the third leading cause of death globally. Through genome-wide association discovery …

Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality
worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed …

Smoking is a major heritable and modifiable risk factor for many diseases, including cancer,
common respiratory disorders and cardiovascular diseases. Fourteen genetic loci have …

Background Genetic factors influence chronic obstructive pulmonary disease (COPD) risk,
but the individual variants that have been identified have small effects. We hypothesised that …

MLKL is the essential effector of necroptosis, a form of programmed lytic cell death. We have
isolated a mouse strain with a single missense mutation, Mlkl D139V , that alters the two-…

Objective Determining the genetic basis of speech disorders provides insight into the
neurobiology of human communication. Despite intensive investigation over the past 2 decades, …

Nearly 100 loci have been identified for pulmonary function, almost exclusively in studies of
European ancestry populations. We extend previous research by meta-analyzing genome-…