Small-molecule inhibition of Axl targets tumor immune suppression and enhances chemotherapy in pancreatic cancer
…, K Wnuk-Lipinska, M Topalovski, JE Toombs, VH Cruz… - Cancer research, 2018 - AACR
Activation of the receptor tyrosine kinase Axl is associated with poor outcomes in pancreatic
cancer (PDAC), where it coordinately mediates immune evasion and drug resistance. Here, …
cancer (PDAC), where it coordinately mediates immune evasion and drug resistance. Here, …
[HTML][HTML] Axl-mediated activation of TBK1 drives epithelial plasticity in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDA) is characterized by an activating mutation in KRAS.
Direct inhibition of KRAS through pharmacological means remains a challenge; however, …
Direct inhibition of KRAS through pharmacological means remains a challenge; however, …
Assessment of TANK-binding kinase 1 as a therapeutic target in cancer
VH Cruz, RA Brekken - Journal of cell communication and signaling, 2018 - Springer
TANK-binding kinase 1 (TBK1) is central to multiple biological processes that promote
tumorigenesis including cell division, autophagy, innate immune response and AKT-pro survival …
tumorigenesis including cell division, autophagy, innate immune response and AKT-pro survival …
[HTML][HTML] Loss of Tbk1 kinase activity protects mice from diet-induced metabolic dysfunction
VH Cruz, EN Arner, KW Wynne, PE Scherer… - Molecular …, 2018 - Elsevier
Objective TANK Binding Kinase 1 (TBK1) has been implicated in the regulation of
metabolism through studies with the drug amlexanox, an inhibitor of the IκB kinase (IKK)-related …
metabolism through studies with the drug amlexanox, an inhibitor of the IκB kinase (IKK)-related …
Comprehensive Ex Vivo Transposon Mutagenesis Identifies Genes That Promote Growth Factor Independence and Leukemogenesis
Aberrant signaling through cytokine receptors and their downstream signaling pathways is a
major oncogenic mechanism underlying hematopoietic malignancies. To better understand …
major oncogenic mechanism underlying hematopoietic malignancies. To better understand …
A rapid in vivo screen for pancreatic ductal adenocarcinoma therapeutics
…, RK Kollipara, Y Zolghadri, VH Cruz… - Disease models & …, 2015 - journals.biologists.com
Pancreatic ductal adenocarcinoma (PDA) is the fourth leading cause of cancer-related deaths
in the United States, and is projected to be second by 2025. It has the worst survival rate …
in the United States, and is projected to be second by 2025. It has the worst survival rate …
Abstract A15: Axl-mediated activation of TBK1 drives epithelial plasticity in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDA) is characterized by an activating mutation in
KRAS, which is critical for the biology of PDA progression. Direct inhibition of KRAS through …
KRAS, which is critical for the biology of PDA progression. Direct inhibition of KRAS through …
Axl-mediated activation of TBK1 drives epithelial plasticity in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDA) is characterized by an activating mutation in KRAS.
Direct inhibition of KRAS through pharmacological means remains a challenge; however, …
Direct inhibition of KRAS through pharmacological means remains a challenge; however, …
Guidelines for on-site assessment of historic timber structures
H Cruz, D Yeomans, E Tsakanika… - International Journal …, 2015 - Taylor & Francis
In the scope of European Cooperation in Science and Technology–Wood Science for
Conservation of Cultural Heritage (COST IE0601–WoodCultHer) (available at http://www.…
Conservation of Cultural Heritage (COST IE0601–WoodCultHer) (available at http://www.…
[PDF][PDF] Loss of TBK1 Kinase Function Improves Disease Outcome in Pancreatic Cancer and Metabolic Syndrome
VH Cruz - 2018 - utswmed-ir.tdl.org
Aberrant expression and activity of TANK binding kinase 1 (TBK1) has been observed in
numerous diseases. Here I've identified novel functions for TBK1 in pancreatic ductal …
numerous diseases. Here I've identified novel functions for TBK1 in pancreatic ductal …