The immediate early gene c-fos is part of the activator protein-1 transcription factor and has
been postulated to participate in the molecular mechanisms of learning and memory. To test …

Novel spatially restricted genetic manipulations can be used to assess contributions made by
synaptic plasticity to learning and memory, not just selectively within the hippocampus, but …

NMDA receptor (NMDAR) 2A (NR2A)- and NR2B-type NMDARs coexist in synapses of CA1
pyramidal cells. Recent studies using pharmacological blockade of NMDAR subtypes …

We generated mouse mutants with targeted AMPA receptor (AMPAR) GluR–B subunit alleles,
functionally expressed at different levels and deficient in Q/R–site editing. All mutant lines …

Gene-targeted mice lacking thel-α-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA)
receptor subunit GluR-A exhibited normal development, life expectancy, and fine structure …

We have investigated the performance of eight popular density functionals, four of which are
“standard” functionals not including dispersion (B3LYP, BP86, PBE, and TPSS) and four of …

NMDA receptors, a class of glutamate-gated cation channels with high Ca 2+ conductance,
mediate fast transmission and plasticity of central excitatory synapses. We show here that …

Synapsin I has been proposed to be involved in the modulation of neurotransmitter release
by controlling the availability of synaptic vesicles for exocytosis. To further understand the …

Controversy revolves around the differential contribution of NR2A- and NR2B-containing
NMDA receptors, which coexist in principal forebrain neurons, to synaptic plasticity and …

A quantitative structure−activity relationship (QSAR) model is presented in which both the
independent and dependent (response) variables are derived from density functional theory (…