TAR DNA binding protein 43 (TDP-43) is a versatile RNA/DNA binding protein involved in
RNA-related metabolism. Hyper-phosphorylated and ubiquitinated TDP-43 deposits act as …

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease associated with
accumulation of hyper-phosphorylated, and ubiquitinated TAR DNA-binding protein-43 (TDP-…

BSA can form amyloid-like aggregates in vitro at 65 C. Heterologous amyloid can proposedly
cross-seed other protein's aggregation, however, general mechanisms and driving …

TDP-43 is an RNA/DNA-binding protein which is also implicated in the pathogenesis of
amyotrophic lateral sclerosis (ALS) disease. TDP-43's cytoplasmic mis-localization, liquid-liquid …

Mutations in adenine biosynthesis pathway genes ADE1 and ADE2 have been conventionally
used to score for prion [PSI + ] in yeast. If ade1‐14 mutant allele is present, which contains …

TDP-43 proteinopathy is implicated in the neurodegenerative diseases, ALS and FTLD-TDP.
Metal ion dyshomeostasis is observed in neurodegenerative diseases including ALS. …

TDP-43 protein is found deposited as inclusions in the amyotrophic lateral sclerosis (ALS)
patient's brain. The mechanism of neuron death in ALS is not fully deciphered but several TDP…

Oxidative stress is a therapeutic target in TDP-43 proteinopathies like amyotrophic lateral
sclerosis (ALS) and FTLD-TDP. TDP-43 over-expression causes oxidative stress in yeast …

Study objective Polycystic ovarian syndrome (PCOS) is a common multifaceted disorder found
among females of the reproductive age presenting major clinical conditions of hirsutism, …

The steadily growing demand for various materials of buildings, the availability of natural
sources was decreasing. It is necessary to use alternative materials for the construction of …