The generation of haploid gametes by meiosis is a highly conserved process for sexually
reproducing organisms that, in almost all cases, involves the extensive breakage of …

Faithful meiotic chromosome segregation and fertility require meiotic recombination between
homologous chromosomes rather than the equally available sister chromatid, a bias that in …

The synaptonemal complex ( SC ) is a proteinaceous macromolecular assembly that forms
during meiotic prophase I and mediates adhesion of paired homologous chromosomes along …

Faithful meiotic chromosome inheritance and fertility rely on the stimulation of meiotic
crossover recombination by potentially genotoxic DNA double-strand breaks (DSBs). To avoid …

In humans, meiotic chromosome segregation errors increase dramatically as women age,
but the molecular defects responsible are largely unknown. Cohesion along the arms of …

Accurate chromosome segregation during meiosis relies on the presence of crossover
events distributed among all chromosomes. MutSγ and MutLγ homologs (Msh4/5 and Mlh1/3) …

Ageing is an intricate phenomenon that starts at pre-harvest and lasts until consumption; but
incompletely understood till date. During ageing, significant changes occur in the …

Normally, meiotic crossovers in conjunction with sister-chromatid cohesion establish a physical
connection between homologs that is required for their accurate segregation during the …

… Subramanian and Andreas Hochwagen … Subramanian, VV, and Bickel, SE (2009).
Heterochromatin-mediated association of achiasmate homologs declines with age when …

Programmed double strand DNA breaks in meiosis can be repaired as inter-homologue
crossovers and thereby aid the faithful segregation of homologous chromosomes. Biased repair …