The 1000 Genomes Project set out to provide a comprehensive description of common human
genetic variation by applying whole-genome sequencing to a diverse set of individuals …

Liver cancer has the second highest worldwide cancer mortality rate and has limited
therapeutic options. We analyzed 363 hepatocellular carcinoma (HCC) cases by whole-exome …

We studied 137 primary testicular germ cell tumors (TGCTs) using high-dimensional assays
of genomic, epigenomic, transcriptomic, and proteomic features. These tumors exhibited …

Myriapods (eg, centipedes and millipedes) display a simple homonomous body plan relative
to other arthropods. All members of the class are terrestrial, but they attained terrestriality …

Gall-forming arthropods are highly specialized herbivores that, in combination with their
hosts, produce extended phenotypes with unique morphologies [1]. Many are economically …

Proteogenomic analysis of triple-negative breast tumors revealed a complex landscape of
chemotherapy response associations, including a 19q13.31–33 somatic deletion encoding …

A small fraction of cancer patients with advanced disease survive significantly longer than
patients with clinically comparable tumors. Molecular mechanisms for exceptional responses …

The advancement of precision medicine requires new methods to coordinate and deliver
genetic data from heterogeneous sources to physicians and patients. The eMERGE III Network …

Purpose The Mayo-Baylor RIGHT 10K Study enabled preemptive, sequence-based
pharmacogenomics (PGx)-driven drug prescribing practices in routine clinical care within a large …

Cooperative systems are susceptible to invasion by selfish individuals that profit from receiving
the social benefits but fail to contribute. These so-called "cheaters" can have a fitness …