The interplay of positive and negative interactions between drug-sensitive and resistant cells
influences the effectiveness of treatment in heterogeneous cancer cell populations. Here, …

Adrenocortical cancer (ACC) is a rare, but agressive malignancy with poor prognosis.
Histopathological diagnosis is challenging and pharmacological options for treatment are limited. …

Background CDK4/6 inhibitors such as ribociclib are becoming widely used targeted therapies
in hormone-receptor-positive (HR+) human epidermal growth factor receptor 2-negative (…

Purpose Multiple endocrine neoplasia type 1 is a rare tumor syndrome caused by germline
mutations of MEN1 gene. Phenotype varies widely, and no definitive correlation with the …

The ongoing COVID-19 pandemic caused by the novel coronavirus, SARS-CoV-2 has affected
all aspects of human society with a special focus on healthcare. Although older patients …

Objective Pancreatic neuroendocrine neoplasms (PanNENs) are rare tumors arising from
the endocrine pancreas; however, their prognosis differs significantly upon their proliferative …

Lynch syndrome (LS) is the most common inherited cancer syndrome. It is inherited via a
monoallelic germline variant in one of the DNA mismatch repair (MMR) genes. LS carriers have …

Inherited, germline mutations of menin-coding MEN1 gene cause multiple endocrine
neoplasia type 1 (MEN1), while somatic MEN1 mutations are the sole main driver mutations in …

In addition to single nucleotide variations and small-scale indels, structural variations (SVs)
also contribute to the genetic diversity of the genome. SVs, such as deletions, duplications, …

Background Previously, drug-based synchronization procedures were used for characterizing
the cell cycle dependent transcriptional program. However, these synchronization …