Three billion years of evolution has produced a tremendous diversity of protein molecules 1
, but the full potential of proteins is likely to be much greater. Accessing this potential has …

ENCoM is a coarse-grained normal mode analysis method recently introduced that unlike
previous such methods is unique in that it accounts for the nature of amino acids. The …

Normal mode analysis (NMA) methods are widely used to study dynamic aspects of protein
structures. Two critical components of NMA methods are coarse-graining in the level of …

Computational protein design can generate proteins not found in nature that adopt desired
structures and perform novel functions. Although proteins could, in theory, be designed with …

In order to bridge the gap between Deep Learning researchers and medical professionals
we develop a very accessible free prototype system which can be used by medical …

Understanding the relationship between protein sequence and structure well enough to
design new proteins with desired functions is a longstanding goal in protein science. Here, we …

… Vincent Frappier and Madeleine Duran contributed equally … Vincent Frappier and Madeleine
Duran contributed equally to … Vincent Frappier and Madeleine Duran contributed equally to …

Steroidogenic acute regulatory-related lipid transfer (START) domain proteins are involved
in the nonvesicular intracellular transport of lipids and sterols. The STARD1 (STARD1 and …

We recently introduced ENCoM, an elastic network atomic contact model, as the first coarse‐grained
normal mode analysis method that accounts for the nature of amino acids and can …

Tuberculosis remains as one of the main cause of mortality worldwide due to a single
infectious agent, Mycobacterium tuberculosis. The aroK-encoded M. tuberculosis Shikimate …