[HTML][HTML] Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration
…, A van Der Spek, Z Wang, J Marten, V Laville… - Nature …, 2019 - nature.com
Both short and long sleep are associated with an adverse lipid profile, likely through different
biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we …
biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we …
[HTML][HTML] Genetic effects on the commensal microbiota in inflammatory bowel disease patients
Several bacteria in the gut microbiota have been shown to be associated with inflammatory
bowel disease (IBD), and dozens of IBD genetic variants have been identified in genome-…
bowel disease (IBD), and dozens of IBD genetic variants have been identified in genome-…
[HTML][HTML] Gene-lifestyle interactions in the genomics of human complex traits
V Laville, T Majarian, YJ Sung, K Schwander… - European Journal of …, 2022 - nature.com
The role and biological significance of gene-environment interactions in human traits and
diseases remain poorly understood. To address these questions, the CHARGE Gene-Lifestyle …
diseases remain poorly understood. To address these questions, the CHARGE Gene-Lifestyle …
NRLiSt BDB, the manually curated nuclear receptors ligands and structures benchmarking database
…, A Jérémie, H Guillemain, V Laville… - Journal of medicinal …, 2014 - ACS Publications
Nuclear receptors (NRs) constitute an important class of drug targets. We created the most
exhaustive NR-focused benchmarking database to date, the NRLiSt BDB (NRs ligands and …
exhaustive NR-focused benchmarking database to date, the NRLiSt BDB (NRs ligands and …
[HTML][HTML] Multitrait GWAS to connect disease variants and biological mechanisms
Genome-wide association studies (GWASs) have uncovered a wealth of associations between
common variants and human phenotypes. Here, we present an integrative analysis of …
common variants and human phenotypes. Here, we present an integrative analysis of …
[HTML][HTML] A conserved NR5A1-responsive enhancer regulates SRY in testis-determination
…, J Bignon-Topalovic, I Gonzalez, V Laville… - Nature …, 2024 - nature.com
The Y-linked SRY gene initiates mammalian testis-determination. However, how the
expression of SRY is regulated remains elusive. Here, we demonstrate that a conserved …
expression of SRY is regulated remains elusive. Here, we demonstrate that a conserved …
Extraocular muscle stem cells exhibit distinct cellular properties associated with non-muscle molecular signatures
…, B Evano, M Kuriki, S Gioftsidi, V Laville… - …, 2024 - journals.biologists.com
Skeletal muscle stem cells (MuSCs) are recognised as functionally heterogeneous. Cranial
MuSCs are reported to have greater proliferative and regenerative capacity when compared …
MuSCs are reported to have greater proliferative and regenerative capacity when compared …
A genome‐wide association study in Caucasian women suggests the involvement of HLA genes in the severity of facial solar lentigines
V Laville, SL Clerc, K Ezzedine, R Jdid… - Pigment cell & …, 2016 - Wiley Online Library
Solar lentigines are a common feature of sun‐induced skin ageing. Little is known, however,
about the genetic factors contributing to their development. In this genome‐wide …
about the genetic factors contributing to their development. In this genome‐wide …
Genetic correlations between diabetes and glaucoma: an analysis of continuous and dichotomous phenotypes
V Laville, JH Kang, CC Cousins, AI Iglesias… - American journal of …, 2019 - Elsevier
Purpose A genetic correlation is the proportion of phenotypic variance between traits that is
shared on a genetic basis. Here we explore genetic correlations between diabetes- and …
shared on a genetic basis. Here we explore genetic correlations between diabetes- and …
[HTML][HTML] Identification of New Biological Pathways Involved in Skin Aging From the Analysis of French Women Genome-Wide Data
M Rahmouni, V Laville, JL Spadoni, R Jdid… - Frontiers in …, 2022 - frontiersin.org
Skin aging is an ineluctable process leading to the progressive loss of tissue integrity and is
characterized by various outcomes such as wrinkling and sagging. Researchers have …
characterized by various outcomes such as wrinkling and sagging. Researchers have …