Background Comprehensive annotation and quantification of transcriptomes are
outstanding problems in functional genomics. While high throughput mRNA sequencing (RNA-Seq) …

Candida albicans is the major invasive fungal pathogen of humans, causing diseases
ranging from superficial mucosal infections to disseminated, systemic infections that are often …

Recognition of conserved bacterial products by innate immune receptors leads to inflammatory
responses that control pathogen spread but that can also result in pathology. Intestinal …

Candida albicans is a commensal fungus that causes diverse infections after antibiotic use or
immune debilitation. Gene discovery has been limited because the organism is an asexual …

Signaling through the IL-17 receptor (IL-17R) is required to prevent oropharyngeal candidiasis
(OPC) in mice and humans. However, the IL-17-responsive cell type(s) that mediate …

Biofilm formation plays a key role in the life cycles and subsistence of many microorganisms.
For the human fungal pathogen Candida albicans, biofilm development is arguably a …

The fungal cell wall is vital for growth, development, and interaction of cells with their
environment. The response to cell wall damage is well understood from studies in the budding …

INTRODUCTION Studies of monogenic diseases have uncovered the importance of
immune pathways in human tissue-specific immunity and antimicrobial defense. In particular, …

ABSTRACT Treatment of vulvovaginal candidiasis (VVC), caused most frequently by Candida
albicans , represents a significant unmet clinical need. C. albicans , as both a commensal …

Advances in transcriptome sequencing allow for simultaneous interrogation of differentially
expressed genes from multiple species originating from a single RNA sample, termed dual or …