Totipotency is the ability of a single cell to give rise to all of the differentiated cell types that
build the conceptus, yet how to capture this property in vitro remains incompletely understood. …

Amphibian oocytes can rapidly and efficiently reprogram the transcription of transplanted
somatic nuclei. To explore the factors and mechanisms involved, we focused on nuclear actin, …

Understanding lineage specification during human pre-implantation development is a gateway
to improving assisted reproductive technologies and stem cell research. Here we employ …

Reprogramming to iPSCs resets the epigenome of somatic cells, including the reversal of X
chromosome inactivation. We sought to gain insight into the steps underlying the …

The ability to study human post-implantation development remains limited owing to ethical
and technical challenges associated with intrauterine development after implantation 1. …

Epigenetic reprogramming in early germ cells is critical toward the establishment of
totipotency, but investigations of the germline events are intractable. An objective cell culture-based …

How various layers of epigenetic repression restrict somatic cell nuclear reprogramming is
poorly understood. The transfer of mammalian somatic cell nuclei into Xenopus oocytes …

Induced pluripotent stem cells (iPSCs) have considerably impacted human developmental
biology and regenerative medicine, notably because they circumvent the use of cells of …

Sox7 and Sox18 are members of the F-subgroup of Sox transcription factors family and are
mostly expressed in endothelial compartments. In humans, dominant mutations in Sox18 are …

Differentiated cells can be experimentally reprogrammed back to pluripotency by nuclear
transfer, cell fusion or induced pluripotent stem cell technology. Nuclear transfer and cell fusion …