Chronic hyperglycemia and hyperlipidemia can exert deleterious effects on β-cell function,
respectively referred to as glucotoxicity and lipotoxicity. Over time, both contribute to the …

The relentless decline in β-cell function frequently observed in type 2 diabetic patients,
despite optimal drug management, has variously been attributed to glucose toxicity and …

The development of an electrochemically based implantable sensor for glucose is described.
The sensor is needle-shaped, about the size of a 28-gauge needle. It is flexible and must …

Glucotoxicity, lipotoxicity, and glucolipotoxicity are secondary phenomena that are proposed
to play a role in all forms of type 2 diabetes. The underlying concept is that once the primary …

The concept of glucolipotoxicity refers to the combined, deleterious effects of elevated glucose,
and fatty acid levels on pancreatic beta-cell function and survival. Significant progress …

Acetaminophen has been one of the most serious electrochemical interferences to oxidase-based
amperometric biosensors that measure H2O2. A study was carried out to investigate …

A miniaturized glucose sensor was developed, consisting of a platinum wire entirely coated
with teflon, except for a 1 mm section near its extremity where glucose oxidase is immobilized…

Prolonged exposure of isolated islets to supraphysiologic concentrations of palmitate
decreases insulin gene expression in the presence of elevated glucose levels. This study was …

The insulin gene is expressed almost exclusively in pancreatic β-cells. Metabolic regulation
of insulin gene expression enables the β-cell to maintain adequate stores of intracellular …

Long-chain fatty acids amplify insulin secretion from the pancreatic β-cell. The G-protein–coupled
receptor GPR40 is specifically expressed in β-cells and is activated by fatty acids; …