The generation of genetic mutants in Caenorhabditis elegans has long relied on the selection
of mutations in large-scale screens. Directed mutagenesis of specific loci in the genome …

Cells are protected from toxic DNA double-stranded breaks (DSBs) by a number of DNA repair
mechanisms, including some that are intrinsically error prone, thus resulting in mutations. …

The position of the mitotic spindle controls the plane of cell cleavage and determines
whether polarized cells divide symmetrically or asymmetrically 1 , 2 , 3 . In animals, an …

SWI/SNF (switch/sucrose nonfermenting) complexes regulate transcription through chromatin
remodeling and opposing gene silencing by Polycomb group (PcG) proteins. Genes …

Cell proliferation and differentiation are regulated in a highly coordinated and inverse manner
during development and tissue homeostasis. Terminal differentiation usually coincides …

During cell division, the mitotic spindle segregates replicated chromosomes to opposite
poles of the cell, while the position of the spindle determines the plane of cleavage. Spindle …

DNA replication and its connection to M phase restraint are studied extensively at the level
of single cells but rarely in the context of a developing animal. C. elegans lin-6 mutants lack …

The microtubule spindle apparatus dictates the plane of cell cleavage in animal cells. During
development, dividing cells control the position of the spindle to determine the size, location…

Cells are protected from toxic DNA double-strand breaks by a number of DNA repair
mechanisms, including some that are intrinsically error-prone, thus resulting in mutations. To what …