Bis‐(3′,5′)‐cyclic‐dimeric‐guanosine monophosphate (c‐di‐GMP) has been shown to be
a global regulatory molecule that modulates the reciprocal responses of bacteria to activate …

Type III secretion systems (TTSSs) are utilized by numerous bacterial pathogens to inject
effector proteins directly into host cells. Using a whole-genome microarray, we investigated the …

The ubiquitous bacterial second messenger c‐di‐GMP regulates the expression of various
virulence determinants in a wide range of bacterial pathogens. Several studies have …

Pseudomonas aeruginosa utilizes a number of distinct pathways to secrete proteins that
play various roles during infection. These include the type II secretion system, which is …

Nucleotide signaling molecules are important messengers in key pathways that allow
cellular responses to changing environments. Canonical secondary signaling molecules act …

The skin, the oral cavity, and the gastrointestinal tract of humans are colonized with bacteria.
Microbial entry into the blood or blood-circulated tissues is hindered by anatomical barriers. …

Interactions of proteins with low-molecular-weight ligands, such as metabolites, cofactors,
and allosteric regulators, are important determinants of metabolism, gene regulation, and …

Pseudomonas aeruginosa is an opportunistic human pathogen that is especially adept at
forming surface-associated biofilms. P. aeruginosa causes catheter-associated urinary tract …

As the application of deep learning continues to grow, so does the amount of data used to
make predictions. While traditionally big-data deep learning was constrained by computing …

The bacterial second messenger cyclic di-GMP (c-di-GMP) controls biofilm formation and
other phenotypes relevant to pathogenesis. Cyclic-di-GMP is synthesized by diguanylate …