Dendritic cells (DC) capture microorganisms that enter peripheral mucosal tissues and then
migrate to secondary lymphoid organs, where they present these in antigenic form to resting …

The replication of human immunodeficiency virus type 1 (HIV-1) in nondividing host cells
such as those of macrophage lineage is an important feature of AIDS pathogenesis. The …

Several members of the chemokine-receptor family serve, in conjunction with CD4, as receptors
for the entry of human immunodeficiency virus type I (HIV-1) into cells 1 , 2 , 3 , 4 , 5 , 6 . …

Monocyte-derived dendritic cells (MDDCs) can efficiently bind and transfer HIV infectivity
without themselves becoming infected. Using live-cell microscopy, we found that HIV was …

Dendritic cells (DCs) are crucial for the generation and the regulation of adaptive immunity.
Because DCs have a pivotal role in marshalling immune responses, HIV has evolved ways …

Lentiviruses such as HIV-1 traverse nuclear pore complexes (NPC) and infect terminally
differentiated non-dividing cells, but how they do this is unclear. The cytoplasmic NPC protein …

HIV-1 replication requires transport of nascent viral DNA and associated virion proteins, the
retroviral preintegration complex (PIC), into the nucleus. Too large for passive diffusion …

Lentiviral vectors have been advocated to be effective vehicles for the delivery and stable
expression of genes in nondividing primary cells. However, certain cell types, such as resting T …

HIV-1 Tat activates transcription through binding to human cyclin T1, a regulatory subunit of
the TAK/P-TEFb CTD kinase complex. Here we show that the cyclin domain of hCycT1 is …

The discovery of dendritic cell (DC)-specific intercellular adhesion molecule (ICAM)-3–grabbing
nonintegrin (DC-SIGN) as a DC-specific ICAM-3 binding receptor that enhances HIV-1 …