[PDF][PDF] Mapping the evolution of T cell states during response and resistance to adoptive cellular therapy
P Bachireddy, E Azizi, C Burdziak, VN Nguyen… - Cell reports, 2021 - cell.com
To elucidate mechanisms by which T cells eliminate leukemia, we study donor lymphocyte
infusion (DLI), an established immunotherapy for relapsed leukemia. We model T cell …
infusion (DLI), an established immunotherapy for relapsed leukemia. We model T cell …
Distinct evolutionary paths in chronic lymphocytic leukemia during resistance to the graft-versus-leukemia effect
P Bachireddy, C Ennis, VN Nguyen, SH Gohil… - Science translational …, 2020 - science.org
Leukemic relapse remains a major barrier to successful allogeneic hematopoietic stem cell
transplantation (allo-HSCT) for aggressive hematologic malignancies. The basis for relapse …
transplantation (allo-HSCT) for aggressive hematologic malignancies. The basis for relapse …
[HTML][HTML] Clonal and Single Cell Dynamics of Resistance to Graft-Versus-Leukemia (GvL) in Chronic Lymphocytic Leukemia (CLL)
…, SA Shukla, S Freeman, L Elagina, VN Nguyen… - Blood, 2018 - Elsevier
Although the GvL effect is the curative basis for allogeneic hematopoietic stem cell
transplantation, the key cellular and molecular mechanisms driving GvL sensitivity and resistance …
transplantation, the key cellular and molecular mechanisms driving GvL sensitivity and resistance …
Erratum: Mapping the evolution of T cell states during response and resistance to adoptive cellular therapy (Cell Reports (2021) 37 (6),(S2211124721014716) …
…, E Azizi, C Burdziak, VN Nguyen… - Cell …, 2023 - mdanderson.elsevierpure.com
(Cell Reports 37, 109992; November 9, 2021) In the originally published version of this
article, an erroneous dbGaP accession number was listed for data availability. The correct …
article, an erroneous dbGaP accession number was listed for data availability. The correct …
Distinct evolutionary paths in chronic lymphocytic leukemia during resistance to graft-versus-leukemia
Resistance to the graft-versus-leukemia (GvL) effect remains the major barrier to successful
allogeneic hematopoietic stem cell transplantation (allo-HSCT) for aggressive hematologic …
allogeneic hematopoietic stem cell transplantation (allo-HSCT) for aggressive hematologic …
Mapping the evolution of T cell states during DLI response and resistance using single-cell data and computational tools
E Azizi, P Bachireddy, VN Nguyen, S Li, DS Neuberg… - Cancer Research, 2019 - AACR
Donor lymphocyte infusion (DLI) is a standard of care and potentially curative
immunotherapy for relapsed leukemia after allogeneic hematopoietic stem cell transplant (allo-SCT). …
immunotherapy for relapsed leukemia after allogeneic hematopoietic stem cell transplant (allo-SCT). …
[HTML][HTML] Distinct Evolutionary Patterns in Chronic Lymphocytic Leukemia (CLL) during Resistance to Graft-Versus-Leukemia (GvL)
The factors mediating GvL resistance following allogeneic stem cell transplant (SCT) in lymphoid
malignancies remain incompletely characterized. Because cell-intrinsic features shape …
malignancies remain incompletely characterized. Because cell-intrinsic features shape …
[HTML][HTML] Mapping the Evolution of T Cell Transcriptional States during DLI Response and Resistance Using Single-Cell Data
P Bachireddy, E Azizi, VN Nguyen, S Li, DS Neuberg… - Blood, 2018 - Elsevier
Donor lymphocyte infusion (DLI) is a potentially curative immune therapy for leukemic relapse
after allogeneic hematopoietic stem cell transplant (allo-SCT). We previously reported that …
after allogeneic hematopoietic stem cell transplant (allo-SCT). We previously reported that …
[HTML][HTML] Single Cell T Cell Maps of Donor Lymphocyte Infusion (DLI) Response and Resistance
P Bachireddy, E Azizi, VN Nguyen, S Li… - Biology of Blood and …, 2019 - Elsevier
DLI can eradicate leukemic relapse after allogeneic hematopoietic stem cell transplant (allo-SCT),
potentially by reversing T cell exhaustion for chronic myelogenous leukemia (CML). …
potentially by reversing T cell exhaustion for chronic myelogenous leukemia (CML). …
ASXL1 Truncating Mutations Drive Leukemic Resistance to T Cell Attack
…, R Pasumarthi, X Leng, O Pasvolsky, V Nguyen… - Blood, 2023 - Elsevier
Restoration of graft-versus leukemia activity underlies the efficacy of donor lymphocyte
infusion (DLI), a curative immunotherapy for leukemic relapse following allogeneic stem cell …
infusion (DLI), a curative immunotherapy for leukemic relapse following allogeneic stem cell …