Fibroblasts display extensive transcriptional heterogeneity, yet functional annotation and
characterization of their heterocellular relationships remains incomplete. Using mass cytometry, …

MicroRNA deregulation is frequent in human colorectal cancers (CRCs), but little is known
as to whether it represents a bystander event or actually drives tumor progression in vivo. We …

FoxO transcription factors play critical roles in cell cycle control and cellular stress responses,
and abrogation of FoxO function promotes focus formation by Myc in vitro. Here we show …

Background and aims Continuing recalcitrance to therapy cements pancreatic cancer (PC)
as the most lethal malignancy, which is set to become the second leading cause of cancer …

Pancreatic ductal adenocarcinoma (PDAC) can be divided into transcriptomic subtypes with
two broad lineages referred to as classical (pancreatic) and squamous. We find that these …

Objective Transcribed-ultraconserved regions (T-UCR) are long non-coding RNAs which
are conserved across species and are involved in carcinogenesis. We studied T-UCRs …

Macroautophagy promotes cellular homeostasis by delivering cytoplasmic constituents to
lysosomes for degradation [Mizushima, Nat. Cell Biol. 20, 521–527 (2018)]. However, while …

While the use of bioluminescent proteins for molecular imaging is a powerful technology to
further our understanding of complex processes, fluorescent labeling with visible light …

Anchorage independent growth is one of the hallmarks of oncogenic transformation. Here
we show that infrared fluorescent protein (iRFP) based assays allow accurate and unbiased …

285 Background: Integrated multi-omic analyses revealed 24% of pancreatic cancer (PC)
harbor defects in DNA damage response (DDR) and a subgroup demonstrate upregulation in …