We describe a human single-nuclei transcriptomic atlas for the substantia nigra (SN), generated
by sequencing approximately 17,000 nuclei from matched cortical and SN samples. We …

Induced pluripotent stem cell (iPSC) technologies have provided in vitro models of
inaccessible human cell types, yielding new insights into disease mechanisms especially for …

Reproducibility in molecular and cellular studies is fundamental to scientific discovery. To
establish the reproducibility of a well-defined long-term neuronal differentiation protocol, we …

Parkinson’s disease (PD) is the second most common neurodegenerative disorder and a
central role for α-synuclein (αSyn; SNCA) in disease aetiology has been proposed based on …

Dystonia is a neurological disorder characterized by sustained or intermittent muscle
contractions causing abnormal movements and postures, often occurring in absence of any …

Single-cell RNA sequencing (scRNA-seq) is a widely used method for identifying cell types
and trajectories in biologically heterogeneous samples, but it is limited in its detection and …

We present a novel ab initio predictor of protein enzymatic class. The predictor can classify
proteins, solely based on their sequences, into one of six classes extracted from the enzyme …

Maternal exposure to stress during pregnancy is associated with an increased risk of
psychiatric disorders in the offspring in later life. The mechanisms through which the effects of …

Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by loss of survival motor
neuron (SMN) protein. While SMN restoration therapies are beneficial, they are not a cure. …

Parkinson’s disease (PD) represents the most common neurodegenerative movement disorder.
We recently identified 16 novel genes associated with PD. In this study, we focused the …