User profiles for Violeta Beleva Guthrie
 | Violeta Beleva GuthrieAssociate Director at AstraZeneca Verified email at astrazeneca.com Cited by 2583 |
Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas
…, MM Streppel, DJ Lucas, N Niknafs, VB Guthrie… - Nature …, 2013 - nature.com
Through exomic sequencing of 32 intrahepatic cholangiocarcinomas, we discovered frequent
inactivating mutations in multiple chromatin-remodeling genes (including BAP1, ARID1A …
inactivating mutations in multiple chromatin-remodeling genes (including BAP1, ARID1A …
[HTML][HTML] Genomic characterization of malignant progression in neoplastic pancreatic cysts
…, CG Fischer, WM Hackeng, V Beleva Guthrie… - Nature …, 2020 - nature.com
Intraductal papillary mucinous neoplasms (IPMNs) and mucinous cystic neoplasms (MCNs)
are non-invasive neoplasms that are often observed in association with invasive pancreatic …
are non-invasive neoplasms that are often observed in association with invasive pancreatic …
CAGI, the Critical Assessment of Genome Interpretation, establishes progress and prospects for computational genetic variant interpretation methods
…, CS Jeong, DT Jones, L Mulin Jun, VB Guthrie… - Genome …, 2024 - cris.unibo.it
Background: The Critical Assessment of Genome Interpretation (CAGI) aims to advance the
state-of-the-art for computational prediction of genetic variant impact, particularly where …
state-of-the-art for computational prediction of genetic variant impact, particularly where …
[HTML][HTML] SubClonal hierarchy inference from somatic mutations: automatic reconstruction of cancer evolutionary trees from multi-region next generation sequencing
Recent improvements in next-generation sequencing of tumor samples and the ability to
identify somatic mutations at low allelic fractions have opened the way for new approaches to …
identify somatic mutations at low allelic fractions have opened the way for new approaches to …
Intraductal papillary mucinous neoplasms arise from multiple independent clones, each with distinct mutations
CG Fischer, VB Guthrie, AM Braxton, L Zheng, P Wang… - Gastroenterology, 2019 - Elsevier
… Subsequently, the slides were stained by crystal-violet diluted 1:4 in 70% ethanol (Sigma
Aldrich, St. Louis, MO) for 30 seconds and dehydrated by ascending ethanol solutions. The …
Aldrich, St. Louis, MO) for 30 seconds and dehydrated by ascending ethanol solutions. The …
Single‐cell sequencing defines genetic heterogeneity in pancreatic cancer precursor lesions
Y Kuboki, CG Fischer, V Beleva Guthrie… - The Journal of …, 2019 - Wiley Online Library
Intraductal papillary mucinous neoplasms (IPMNs) are precursors to pancreatic cancer;
however, little is known about genetic heterogeneity in these lesions. The objective of this study …
however, little is known about genetic heterogeneity in these lesions. The objective of this study …
Multiregion whole-exome sequencing of intraductal papillary mucinous neoplasms reveals frequent somatic KLF4 mutations predominantly in low-grade regions
…, Q Song, JG Reiter, L Zheng, VB Guthrie… - Gut, 2021 - gut.bmj.com
Objective Intraductal papillary mucinous neoplasms (IPMNs) are non-invasive precursor
lesions that can progress to invasive pancreatic cancer and are classified as low-grade or high-…
lesions that can progress to invasive pancreatic cancer and are classified as low-grade or high-…
Critical assessment of genome interpretation consortium. CAGI, the critical assessment of genome interpretation, establishes progress and pprospects for …
…, D Kim, CS Jeong, TJ David, MJ Li, VB Guthrie… - Genome …, 2024 - iris.uniroma1.it
Background: The Critical Assessment of Genome Interpretation (CAGI) aims to advance the
state-of-the-art for computational prediction of genetic variant impact, particularly where …
state-of-the-art for computational prediction of genetic variant impact, particularly where …
Evaluation of machine learning methods to predict peptide binding to MHC Class I proteins
Binding of peptides to Major Histocompatibility Complex (MHC) proteins is a critical step in
immune response. Peptides bound to MHCs are recognized by CD8+ (MHC Class I) and CD4…
immune response. Peptides bound to MHCs are recognized by CD8+ (MHC Class I) and CD4…
Validation of a Circulating Tumor DNA-Based Next-Generation Sequencing Assay in a Cohort of Patients with Solid tumors: A Proposed Solution for Decentralized …
Background Characterization of circulating tumor DNA (ctDNA) has been integrated into clinical
practice. Although labs have standardized validation procedures to develop single locus …
practice. Although labs have standardized validation procedures to develop single locus …