Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease and a worldwide
health challenge. Different therapeutic approaches are being developed to reverse or slow …

Human brains are prone to neurodegeneration, given that endogenous neural stem/progenitor
cells (NSPCs) fail to support neurogenesis. To investigate the molecular programs …

Neural stem cells (NSCs) constitute an endogenous reservoir for neurons that could potentially
be harnessed for regenerative therapies in disease contexts such as neurodegeneration. …

It was recently suggested that supplying the brain with new neurons could counteract Alzheimer’s
disease (AD). This provocative idea requires further testing in experimental models in …

Alzheimer's disease (AD) is a debilitating neurodegenerative disease in which accumulation
of toxic amyloid-β42 (Aβ42) peptides leads to synaptic degeneration, inflammation, …

Microtubule-associated TAU protein is a pathological hallmark in Alzheimer’s disease (AD),
where hyperphosphorylation of TAU generates neurofibrillary tangles. To investigate the …

Astrocytes are an abundant cell type in the vertebrate central nervous system and can act
as neural stem cells in specialized niches where they constitutively generate new neurons. …

Recent findings suggest that reduced neurogenesis could be one of the underlying reasons
for the exacerbated neuropathology in humans, thus restoring the neural stem cell …

Three-dimensional models of human neural development and neurodegeneration are
crucial when exploring stem-cell-based regenerative therapies in a tissue-mimetic manner. …

The immune response is an important determinant of the plasticity and neurogenic capacity
of neural stem cells (NSCs) upon amyloid-beta42 (Aβ42) toxicity in Alzheimer’s disease (AD)…