Transcription is epigenetically regulated by the orchestrated function of chromatin-binding
proteins that tightly control the expression of master transcription factors, effectors, and …

EP300, but not CBP, controls oncogenic CRC-driven transcription in high-risk NB by binding
TFAP2β. We developed JQAD1, a CRBN-dependent PROTAC degrader with preferential …

Proteasome inhibition is an effective treatment for multiple myeloma (MM); however, targeting
different components of the ubiquitin–proteasome system (UPS) remains elusive. Our RNA…

We delineate the function of KDM5A in activating the MYC-driven transcriptional landscape.
We develop a cell-permeable KDM5 inhibitor to define the activating role of KDM5A on MYC …

The use of epigenetic bromodomain inhibitors as anticancer therapeutics has transitioned
from targeting bromodomain extraterminal domain (BET) proteins into targeting non-BET …

The double membrane architecture of Gram-negative bacteria forms a barrier that is
impermeable to most extracellular threats. Bacteriocin proteins evolved to exploit the accessible, …

Inhibition of the Hsp90 C-terminus is an attractive therapeutic approach for the treatment of
cancer. Novobiocin, the first Hsp90 C-terminal inhibitor identified, contains a synthetically …

Although the exact cause or causes of Parkinson’s disease (PD) are not fully understood, it
is believed that environmental factors play a major role. The discovery that a synthetic …

Problem: All trainees, especially those from historically minoritized backgrounds, experience
stresses that may reduce their continuation in science, technology, engineering, math, and …

The double membrane architecture of Gram-negative bacteria forms a barrier that is effectively
impermeable to extracellular threats. Accordingly, researchers have shown increasing …