Pathogen-sugar interactions revealed by universal saturation transfer analysis

…, G Papadakis, LP Deimel, V Casablancas-Antràs… - Science, 2022 - science.org
Many pathogens exploit host cell-surface glycans. However, precise analyses of glycan
ligands binding with heavily modified pathogen proteins can be confounded by overlapping …

Cryptic pathogen-sugar interactions revealed by universal saturation transfer analysis

…, G Papadakis, LP Deimel, V Casablancas-Antràs… - BioRxiv, 2021 - biorxiv.org
Many host pathogen interactions such as human viruses (including non-SARS-coronaviruses)
rely on attachment to host cell-surface glycans. There are conflicting reports about …

Seedless: On-the-fly pulse calculation for NMR experiments

…, C Buchanan, G Karunanithy, V Casablancas-Antras… - bioRxiv, 2024 - biorxiv.org
All NMR experiments require sequences of RF pulses to manipulate nuclear spins. Signal is
lost due to non-uniform excitation of nuclear spins resonating at different energies (chemical …

[PDF][PDF] Catalytic antibody aldolase 38C2: rationale and biomedical applications

V Casablancas Antràs - 2014 - ddd.uab.cat
Starting question:“Can catalytic antibodies (and if they do, how) be considered a paradigmatic
example of how closely basic research is intertwined with knowledge of pathology/design …

[PDF][PDF] Mechanism of tau R3 aggregation and inhibition revealed by NMR-based chemical kinetics

V Casablancas-Antras, S Demanze, G Sharman… - Biophysical …, 2022 - cell.com
Protein misfolding diseases are becoming increasingly prevalent with the increase in life
expectancy and lifestyle changes over the last century, and constitute a health challenge at a …

[PDF][PDF] Cryptic SARS-CoV2-spike-with-sugar interactions revealed by 'universal'saturation transfer analysis

…, G Papadakis, LP Deimel, V Casablancas-Antràs… - scholar.archive.org
Both SARS-CoV-11-3 and SARS-CoV-24, 5 gain entry to host cells through the use of
receptor-binding domains (RBDs) of their respective spike proteins that bind human cell-surface …

Cryptic SARS-CoV2-spike-with-sugar interactions revealed by'universal'saturation transfer analysis (preprint)

…, G Papadakis, LP Deimel, V Casablancas-Antras… - 2021 - pesquisa.bvsalud.org
Host-expressed proteins on both host-cell and pathogen surfaces are widely exploited by
pathogens, mediating cell entry (and exit) and influencing disease progression and …

Small molecule modulation of a redox-sensitive stress granule protein dissolves stress granules with beneficial outcomes for familial amyotrophic lateral sclerosis …

…, S Kishigami, V Casablancas-Antras… - bioRxiv, 2019 - biorxiv.org
Neurodegeneràve diseases such as amyotrophic lateral sclerosis (ALS) are oten associated
with mutàons in proteins that are associated with stress granules. Stress granules are …

[PDF][PDF] Why We Sleep: it is high time we slept deeper in order to dream bigger.

V Casablancas-Antras, M Walker - 2019 - st-annes-mcr.org.uk
There are many aspects of Sagan’s quote that are in dialogue with Matthew Walkers Why
We Sleep. A British medical doctor turned sleep researcher, Walker is totally in love with the …

[PDF][PDF] The Book of Why, by Judea Pearl & Dana Mackenzie. A book about how we ask questions and how to ask (and solve) better questions.

A Soto-Mota - st-annes-mcr.org.uk
Engaging in the cause-effect analysis is something we cannot escape doing. Regardless of
what you study, regardless of where you live, regardless of when you grew up, we all make …