[HTML][HTML] Current status of latency reversing agents facing the heterogeneity of HIV-1 cellular and tissue reservoirs
One of the most explored therapeutic approaches aimed at eradicating HIV-1 reservoirs is
the “shock and kill” strategy which is based on HIV-1 reactivation in latently-infected cells (“…
the “shock and kill” strategy which is based on HIV-1 reactivation in latently-infected cells (“…
[HTML][HTML] Microglial cells: the main HIV-1 reservoir in the brain
…, F Daouad, S De Wit, V Gautier… - Frontiers in cellular …, 2019 - frontiersin.org
Despite efficient combination of the antiretroviral therapy (cART), which significantly decreased
mortality and morbidity of HIV-1 infection, a definitive HIV cure has not been achieved. …
mortality and morbidity of HIV-1 infection, a definitive HIV cure has not been achieved. …
[HTML][HTML] In vitro nuclear interactome of the HIV-1 Tat protein
VW Gautier, L Gu, N O'Donoghue, S Pennington… - Retrovirology, 2009 - Springer
Background One facet of the complexity underlying the biology of HIV-1 resides not only in
its limited number of viral proteins, but in the extensive repertoire of cellular proteins they …
its limited number of viral proteins, but in the extensive repertoire of cellular proteins they …
[HTML][HTML] Inhibition of HIV-1 gene transcription by KAP1 in myeloid lineage
…, B Fahrenkrog, C Schwartz, C Van Lint, V Gautier… - Scientific reports, 2021 - nature.com
HIV-1 latency generates reservoirs that prevent viral eradication by the current therapies. To
find strategies toward an HIV cure, detailed understandings of the molecular mechanisms …
find strategies toward an HIV cure, detailed understandings of the molecular mechanisms …
On the way to find a cure: Purging latent HIV-1 reservoirs
C Schwartz, S Bouchat, C Marban, V Gautier… - Biochemical …, 2017 - Elsevier
Introduction of cART in 1996 has drastically increased the life expectancy of people living
with HIV-1. However, this treatment has not allowed cure as cessation of cART is associated …
with HIV-1. However, this treatment has not allowed cure as cessation of cART is associated …
[HTML][HTML] Nucleolar protein trafficking in response to HIV-1 Tat: rewiring the nucleolus
…, B Roe, K Wynne, G Elia, WW Hall, VW Gautier - PLoS …, 2012 - journals.plos.org
The trans-activator Tat protein is a viral regulatory protein essential for HIV-1 replication. Tat
trafficks to the nucleoplasm and the nucleolus. The nucleolus, a highly dynamic and …
trafficks to the nucleoplasm and the nucleolus. The nucleolus, a highly dynamic and …
[HTML][HTML] Distinct receptor binding domain IgG thresholds predict protective host immunity across SARS-CoV-2 variants and time
SARS-CoV-2 neutralising antibodies provide protection against COVID-19. Evidence from
early vaccine trials suggested binding antibody thresholds could serve as surrogate markers …
early vaccine trials suggested binding antibody thresholds could serve as surrogate markers …
Proteomic profiling of the human T-cell nucleolus
…, K Wynne, G Elia, WW Hall, VW Gautier - Molecular immunology, 2011 - Elsevier
The nucleolus, site of ribosome biogenesis, is a dynamic subnuclear organelle involved in
diverse cellular functions. The size, number and organisation of nucleoli are cell-specific and …
diverse cellular functions. The size, number and organisation of nucleoli are cell-specific and …
Specific ion effects on macromolecular interactions in Escherichia coli extracts
C Kyne, B Ruhle, VW Gautier, PB Crowley - Protein Science, 2015 - Wiley Online Library
Protein characterization in situ remains a major challenge for protein science. Here, the
interactions of ΔTat‐GB1 in Escherichia coli cell extracts were investigated by NMR …
interactions of ΔTat‐GB1 in Escherichia coli cell extracts were investigated by NMR …
[HTML][HTML] Novel role of UHRF1 in the epigenetic repression of the latent HIV-1
…, C Rouzioux, S De Wit, B Berkhout, V Gautier… - …, 2022 - thelancet.com
Background The multiplicity, heterogeneity, and dynamic nature of human immunodeficiency
virus type-1 (HIV-1) latency mechanisms are reflected in the current lack of functional cure …
virus type-1 (HIV-1) latency mechanisms are reflected in the current lack of functional cure …