Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice
Alveolar cell apoptosis is involved in the pathogenesis of emphysema, a prevalent disease
primarily caused by cigarette smoking. We report that ceramide, a second messenger lipid, is …
primarily caused by cigarette smoking. We report that ceramide, a second messenger lipid, is …
[HTML][HTML] Reactive oxygen species at the crossroads of inflammasome and inflammation
A Harijith, DL Ebenezer, V Natarajan - Frontiers in physiology, 2014 - frontiersin.org
Inflammasomes form a crucial part of the innate immune system. These are multi-protein
oligomer platforms that are composed of intracellular sensors which are coupled with caspase …
oligomer platforms that are composed of intracellular sensors which are coupled with caspase …
FastPlace: Efficient analytical placement using cell shifting, iterative local refinement and a hybrid net model
N Viswanathan, CCN Chu - … of the 2004 international symposium on …, 2004 - dl.acm.org
In this paper, we present FastPlace -- a fast, iterative, flat placement algorithm for large-scale
standard cell designs. FastPlace is based on the quadratic placement approach. The …
standard cell designs. FastPlace is based on the quadratic placement approach. The …
FastPlace 3.0: A fast multilevel quadratic placement algorithm with placement congestion control
N Viswanathan, M Pan, C Chu - 2007 Asia and South Pacific …, 2007 - ieeexplore.ieee.org
In this paper, we present FastPlace 3.0 - an efficient and scalable multilevel quadratic placement
algorithm for large-scale mixed-size designs. The main contributions of our work are: (1…
algorithm for large-scale mixed-size designs. The main contributions of our work are: (1…
Microtubule disassembly induces cytoskeletal remodeling and lung vascular barrier dysfunction: role of Rho‐dependent mechanisms
…, K Kaibuchi, A Ricks‐Cord, V Natarajan… - Journal of cellular …, 2004 - Wiley Online Library
Barrier dysfunction of pulmonary endothelial monolayer is associated with dramatic cytoskeletal
reorganization, activation of actomyosin contractility, and gap formation. The linkage …
reorganization, activation of actomyosin contractility, and gap formation. The linkage …
An efficient and effective detailed placement algorithm
M Pan, N Viswanathan, C Chu - ICCAD-2005. IEEE/ACM …, 2005 - ieeexplore.ieee.org
In the past few years, there has been a lot of research in the area of global placement. In
comparison, not much attention has been paid to the detailed placement problem. Existing …
comparison, not much attention has been paid to the detailed placement problem. Existing …
Role of sphingosine-1 phosphate in the enhancement of endothelial barrier integrity by platelet-released products
…, KN Jacobs, A Zaiman, V Natarajan… - … of Physiology-Lung …, 2003 - journals.physiology.org
In vitro and in vivo evidence indicates that circulating platelets affect both vascular integrity
and hemostasis. How platelets enhance the permeability barrier of the vascular endothelium …
and hemostasis. How platelets enhance the permeability barrier of the vascular endothelium …
Ethnic differences and functional analysis of MET mutations in lung cancer
Purpose: African Americans have higher incidence and poorer response to lung cancer
treatment compared with Caucasians. However, the underlying molecular mechanisms for the …
treatment compared with Caucasians. However, the underlying molecular mechanisms for the …
Role of Nox4 and Nox2 in hyperoxia-induced reactive oxygen species generation and migration of human lung endothelial cells
…, JD Lambeth, VJ Thannickal, V Natarajan - Antioxidants & redox …, 2009 - liebertpub.com
In vascular endothelium, the major research focus has been on reactive oxygen species (ROS)
derived from Nox2. The role of Nox4 in endothelial signal transduction, ROS production, …
derived from Nox2. The role of Nox4 in endothelial signal transduction, ROS production, …
Differential effects of sphingosine 1–phosphate receptors on airway and vascular barrier function in the murine lung
…, JR Jacobson, SM Dudek, V Natarajan… - American journal of …, 2010 - atsjournals.org
The therapeutic options for ameliorating the profound vascular permeability, alveolar
flooding, and organ dysfunction that accompanies acute inflammatory lung injury (ALI) remain …
flooding, and organ dysfunction that accompanies acute inflammatory lung injury (ALI) remain …