Gene regulation by cytokine-activated transcription factors of the signal transducer and activator
of transcription (STAT) family requires serine phosphorylation within the transactivation …

Toll-like receptors (TLRs) have a crucial role in the recognition of pathogens and initiation of
immune responses 1 , 2 – 3 . Here we show that a previously uncharacterized protein …

In genetic screens aimed at understanding drug resistance mechanisms in chronic myeloid
leukemia cells, inactivation of the cullin 3 adapter protein-encoding leucine zipper-like …

About a thousand genes in the human genome encode for membrane transporters. Among
these, several solute carrier proteins (SLCs), representing the largest group of transporters, …

Solute carriers (SLCs) are the largest family of transmembrane transporters in humans and
are major determinants of cellular metabolism. Several SLCs have been shown to be …

For a successful yet controlled immune response, cells need to specifically destabilize
inflammatory mRNAs but prevent premature removal of those still used. The regulatory circuits …

The Innovative Medicines Initiative Consortium RESOLUTE has started to develop tools and
produce data sets to de-orphanize transporters in the solute carrier protein (SLC) …

Muscle degeneration is the most prevalent cause for frailty and dependency in inherited
diseases and ageing. Elucidation of pathophysiological mechanisms, as well as effective …

HuR is an RNA-binding protein implicated in immune homeostasis and various cancers,
including colorectal cancer. HuR binding to AU-rich elements within the 3′ untranslated region …

AREsite2 represents an update for AREsite , an on-line resource for the investigation of AU-rich
elements (ARE) in human and mouse mRNA 3′UTR sequences. The new updated and …