To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome
sequencing of 1,439 cases and 720 controls, imputed discovered sequence variants …

Physical activity has been associated with lower risks of breast and colorectal cancer in
epidemiological studies; however, it is unknown if these associations are causal or confounded. …

Background & Aims Human studies examining associations between circulating levels of
insulin-like growth factor 1 (IGF1) and insulin-like growth factor binding protein 3 (IGFBP3) and …

… Catherine Dong, Antoine Meyer and Vittorio Perduca contributed to statistical analysis.
All the authors had access to the study data and reviewed and approved the final manuscript. …

Objective An understanding of the etiologic heterogeneity of colorectal cancer (CRC) is critical
for improving precision prevention, including individualized screening recommendations …

Background DNA methylation changes in peripheral blood have recently been identified in
relation to lung cancer risk. Some of these changes have been suggested to mediate part of …

Background Socio-economic inequalities in mortality are well established, yet the contribution
of intermediate risk factors that may underlie these relationships remains unclear. We …

Purpose: Renal cell carcinoma (RCC) has the potential for cure with surgery when diagnosed
at an early stage. Kidney injury molecule-1 (KIM-1) has been shown to be elevated in the …

Background Acute severe ulcerative colitis (ASUC) is a life‐threatening condition. Mortality
in ASUC decreased in published series but there is uncertainty as to whether this also …

Mutational signatures refer to patterns in the occurrence of somatic mutations that might be
uniquely ascribed to particular mutational process. Tumour mutation catalogues can reveal …