User profiles for Vivek Iyer

Vivek Iyer

- Verified email at unentschlossen.com - Cited by 11877

Vivek Iyer

- Verified email at columbia.edu - Cited by 1774

Some properties of the Noether charge and a proposal for dynamical black hole entropy

V Iyer, RM Wald - Physical review D, 1994 - APS
We consider a general, classical theory of gravity with arbitrary matter fields in n dimensions,
arising from a diffeomorphism-invariant Lagrangian L. We first show that L alwasy can be …

A conditional knockout resource for the genome-wide study of mouse gene function

…, B Rosen, AP West, M Koutsourakis, W Bushell, V Iyer… - Nature, 2011 - nature.com
Gene targeting in embryonic stem cells has become the principal technology for manipulation
of the mouse genome, offering unrivalled accuracy in allele design and access to …

Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects

…, J Zhou, J Wang, L Chen, L Wang, A Hodgkins, V Iyer… - Nature …, 2014 - nature.com
Bacterial RNA–directed Cas9 endonuclease is a versatile tool for site-specific genome
modification in eukaryotes. Co-microinjection of mouse embryos with Cas9 mRNA and single …

Second international guidelines for the diagnosis and management of hereditary hemorrhagic telangiectasia

…, K Heimdal, K Henderson, VN Iyer… - Annals of internal …, 2020 - acpjournals.org
Description: Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disease
with an estimated prevalence of 1 in 5000 that is characterized by the presence of vascular …

An overview of Ensembl

…, J Gilbert, M Hammond, HR Hotz, V Iyer… - Genome …, 2004 - genome.cshlp.org
Ensembl ( http://www.ensembl.org/ ) is a bioinformatics project to organize biological
information around the sequences of large genomes. It is a comprehensive source of stable …

[HTML][HTML] Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes

…, A Evans, D Gannon, M Griffiths, S Holroyd, V Iyer… - Cell, 2013 - cell.com
Mutations in whole organisms are powerful ways of interrogating gene function in a realistic
context. We describe a program, the Sanger Institute Mouse Genetics Project, that provides …

Comparison of the Noether charge and Euclidean methods for computing the entropy of stationary black holes

V Iyer, RM Wald - Physical Review D, 1995 - APS
The entropy of stationary black holes has recently been calculated by a number of different
approaches. Here we compare the Noether charge approach (defined for any …

[HTML][HTML] Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis

…, M Gu, T Jiang, J Mitchell, R Langdon, V Iyer… - Nature Genetics, 2022 - nature.com
Clonal hematopoiesis (CH), the clonal expansion of a blood stem cell and its progeny driven
by somatic driver mutations, affects over a third of people, yet remains poorly understood. …

Ensembl 2005

…, J Herrero, H Hotz, K Howe, V Iyer… - Nucleic acids …, 2005 - academic.oup.com
The Ensembl ( http://www.ensembl.org/ ) project provides a comprehensive and integrated
source of annotation of large genome sequences. Over the last year the number of genomes …

[HTML][HTML] A computational model of the human left-ventricular epicardial myocyte

V Iyer, R Mazhari, RL Winslow - Biophysical journal, 2004 - cell.com
A computational model of the human left-ventricular epicardial myocyte is presented. Models
of each of the major ionic currents present in these cells are formulated and validated using …