[PDF][PDF] Progressive aggregation of alpha-synuclein and selective degeneration of lewy inclusion-bearing neurons in a mouse model of parkinsonism
…, KJ Spinelli, LJ Weston, KC Luk, RL Woltjer, VK Unni - Cell reports, 2015 - cell.com
Aggregated alpha-synuclein inclusions are found where cell death occurs in several diseases,
including Parkinson's disease, dementia with Lewy bodies, and multiple-system atrophy. …
including Parkinson's disease, dementia with Lewy bodies, and multiple-system atrophy. …
Presynaptic alpha-synuclein aggregation in a mouse model of Parkinson's disease
…, E Pollock, C Moore, CK Meshul, VK Unni - Journal of …, 2014 - Soc Neuroscience
Parkinson's disease and dementia with Lewy bodies are associated with abnormal neuronal
aggregation of α-synuclein. However, the mechanisms of aggregation and their relationship …
aggregation of α-synuclein. However, the mechanisms of aggregation and their relationship …
Distinct roles in vivo for the ubiquitin–proteasome system and the autophagy–lysosomal pathway in the degradation of α-synuclein
Increased intracellular levels of α-synuclein are implicated in Parkinson's disease and related
disorders and may be caused by alterations in the ubiquitin–proteasome system (UPS) or …
disorders and may be caused by alterations in the ubiquitin–proteasome system (UPS) or …
[HTML][HTML] Age, sex, and apolipoprotein E isoform alter contextual fear learning, neuronal activation, and baseline DNA damage in the hippocampus
SW Boutros, B Zimmerman, SC Nagy, VK Unni… - Molecular …, 2023 - nature.com
Age, female sex, and apolipoprotein E4 (E4) are risk factors to develop Alzheimer’s disease
(AD). There are three major human apoE isoforms: E2, E3, and E4. Compared to E3, E4 …
(AD). There are three major human apoE isoforms: E2, E3, and E4. Compared to E3, E4 …
G2019S-LRRK2 expression augments α-synuclein sequestration into inclusions in neurons
…, JPL Daher, AJ Milnerwood, VK Unni… - Journal of …, 2016 - Soc Neuroscience
Pathologic inclusions define α-synucleinopathies that include Parkinson's disease (PD). The
most common genetic cause of PD is the G2019S LRRK2 mutation that upregulates LRRK2 …
most common genetic cause of PD is the G2019S LRRK2 mutation that upregulates LRRK2 …
Mutations in XPR1 cause primary familial brain calcification associated with altered phosphate export
…, P Striano, P Svenningsson, F Tison, VK Unni… - Nature …, 2015 - nature.com
Primary familial brain calcification (PFBC) is a neurological disease characterized by calcium
phosphate deposits in the basal ganglia and other brain regions and has thus far been …
phosphate deposits in the basal ganglia and other brain regions and has thus far been …
[HTML][HTML] Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders
…, KC Luk, AK McCullough, RL Woltjer, VK Unni - Scientific reports, 2019 - nature.com
Alpha-synuclein is a presynaptic protein that forms abnormal cytoplasmic aggregates in
Lewy body disorders. Although nuclear alpha-synuclein localization has been described, its …
Lewy body disorders. Although nuclear alpha-synuclein localization has been described, its …
[HTML][HTML] Curcumin treatment improves motor behavior in α-synuclein transgenic mice
…, VR Osterberg, CK Meshul, A Soumyanath, VK Unni - PloS one, 2015 - journals.plos.org
The curry spice curcumin plays a protective role in mouse models of neurodegenerative
diseases, and can also directly modulate aggregation of α-synuclein protein in vitro, yet no …
diseases, and can also directly modulate aggregation of α-synuclein protein in vitro, yet no …
Alpha-synuclein's degradation in vivo: opening a new (cranial) window on the roles of degradation pathways in Parkinson disease
D Ebrahimi-Fakhari, PJ McLean, VK Unni - Autophagy, 2012 - Taylor & Francis
Progressive accumulation of α-synuclein is key to the pathology of many neurodegenerative
diseases, including Parkinson disease and dementia with Lewy bodies. Increased …
diseases, including Parkinson disease and dementia with Lewy bodies. Increased …
Calcium release from presynaptic ryanodine-sensitive stores is required for long-term depression at hippocampal CA3-CA3 pyramidal neuron synapses
VK Unni, SS Zakharenko, L Zablow… - Journal of …, 2004 - Soc Neuroscience
Although Ca 2+ release from internal stores has been proposed to be important for the induction
of long-term synaptic plasticity, the importance of Ca 2+ stores localized in presynaptic …
of long-term synaptic plasticity, the importance of Ca 2+ stores localized in presynaptic …