Complex traits and disease comorbidity in humans and in model organisms are the result of
naturally occurring polymorphisms that interact with each other and with the environment. To …

Contemporary mouse genetic reference populations are a powerful platform to discover
complex disease mechanisms. Advanced high-diversity mouse populations include the …

Glaucomas are neurodegenerative diseases that cause vision loss, especially in the elderly.
The mechanisms initiating glaucoma and driving neuronal vulnerability during normal …

We present a consensus atlas of the human brain transcriptome in Alzheimer's disease (AD),
based on meta-analysis of differential gene expression in 2,114 postmortem samples. We …

Inbred mice are preferred over outbred mice because it is assumed that they display less trait
variability. We compared coefficients of variation and did not find evidence of greater trait …

Genetic reference populations, particularly the BXD recombinant inbred (BXD RI) strains
derived from C57BL/6J and DBA/2J mice, are a valuable resource for the discovery of the bio‐…

Genetic reference populations in model organisms are critical resources for systems genetic
analysis of disease related phenotypes. The breeding history of these inbred panels may …

Transgenesis has been a mainstay of mouse genetics for over 30 yr, providing numerous
models of human disease and critical genetic tools in widespread use today. Generated …

The gut microbiome is thought to play a critical role in the onset and development of
psychiatric disorders, including depression and substance use disorder (SUD). To test the …

Cardiac ischemia leads to the loss of myocardial tissue and the activation of a repair process
that culminates in the formation of a scar whose structural characteristics dictate propensity …