PTEN, a lipid phosphatase, is one of the most frequently mutated tumour suppressors in
human cancer. Several recent studies have highlighted the importance of ubiquitylation in …

Intraflagellar transport (IFT) complexes, IFT-A and IFT-B, form bidirectional trains that move
along the axonemal microtubules and are essential for assembling and maintaining cilia. …

Ubiquitination is an important post-translational modification that is implicated in controlling
almost every biological process by targeting cellular proteins to degradation. While the …

The primary cilium is a nexus for cell signaling and relies on specific protein trafficking for
function. The tubby family protein TULP3 transports integral membrane proteins into cilia …

Polycystic kidney disease proteins, polycystin-1 and polycystin-2, localize to primary cilia.
Polycystin knockouts have severe cystogenesis compared to ciliary disruption, whereas …

The mechanisms underlying subcellular targeting of cAMP-generating adenylyl cyclases
and processes regulated by their compartmentalization are poorly understood. Here, we …

Primary cilia play counterregulatory roles in cystogenesis—they inhibit cyst formation in the
normal renal tubule but promote cyst growth when the function of polycystins is impaired. Key …

Patient variants in Tubby Like Protein-3 (TULP3) have recently been associated with progressive
fibrocystic disease in tissues and organs. TULP3 is a ciliary trafficking protein that links …

The tubby family protein–TULP3 coordinates with the intraflagellar transport complex-A (IFT-A)
in trafficking certain transmembrane proteins to cilia. These transmembrane cargoes …

HECT‐E3 ligases play an essential role in catalyzing the transfer of ubiquitin to protein
substrates. The noncatalytic roles of HECT‐E3 ligases in cells are unknown. Here, we report that …