Photobiological processes in nature are usually triggered by nonpeptidic chromophores or
by modified side chains. A system is presented in which the polypeptide backbone itself can …

The goal of xenobiology is to design biological systems endowed with unusual biochemical
functions, whereas enzymology concerns the study of enzymes, the workhorses of …

The peptide bond formation with the amino acid proline (Pro) on the ribosome is slow,
resulting in translational stalling when several Pro have to be incorporated into the peptide. …

Protein halogenation is a common non-enzymatic post-translational modification contributing
to aging, oxidative stress-related diseases and cancer. Here, we report a genetically …

The synthesis of multifunctional spirocycles was achieved from common cyclic carboxylic
acids (cyclobutane carboxylate, cyclopentane carboxylate, l‐proline, etc.). The whole …

γ-(4S)-Trifluoromethyl proline was synthesised according to a modified literature protocol with
improved yield on a multigram scale. Conformational properties of the amide bond formed …

Organofluorine compounds are known to be toxic to a broad variety of living beings in
different habitats, and chemical fluorination has been historically exploited by mankind for the …

Structural biology relies heavily on NMR studies of peptides and proteins that are uniformly
or selectively labeled with NMR-active isotopes (2H, 13C, 15N, 19F). One of the most …

The triple-helical structure of collagen, the most abundant protein in animal bodies, owes its
stability to post-translationally installed hydroxyl groups at position 4 of prolyl residues. To …

Collagen mimics are peptides designed to reproduce structural features of natural collagen.
A triple helix is the first element in the hierarchy of collagen folding. It is an assembly of three …