Platelet-derived growth factor (PDGF) is a mitogen and chemoattractant for vascular smooth
muscle cells (SMC) in vitro, but its activities in vivo remain largely undefined. We infused …

The ability of gene targeting in the mouse species presents a powerful tool to determine the
role of specific molecules in vascular biology. Using a denuding-injury procedure, we …

A number of pathophysiologically relevant genes, including platelet-derived growth factor B-chain
(PDGF-B), are induced in the vasculature after acute mechanical injury. In rat aorta, …

Repair of arterial injury produced by balloon angioplasty leads to the formation of a neointima
and a narrowing of the vascular lumen. In this study, we examined the possibility that …

In the present study, we established an injury model of the mouse carotid artery. Complete
removal of the endothelium was achieved with a flexible wire. A platelet monolayer covered …

In the present study we investigated whether basic fibroblast growth factor (bFGF) plays a role
in the proliferative response of smooth muscle cells (SMCs) to denuding injury. Rat carotid …

TWEAK is a member of the TNF ligand family that induces angiogenesis in vivo. We report
cloning of a receptor for TWEAK (TweakR) from a human umbilical vein endothelial cell (…

Pericytes are essential for normal brain function, but many aspects of their physiology
remain enigmatic due to a lack of tools to genetically target this cell population. Here, we …

Collagen triple helix repeat containing 1 (Cthrc1) was identified in a screen for differentially
expressed sequences in balloon-injured versus normal arteries. Cthrc1 expression was not …

Estrogen exerts direct effects on vascular endothelial and smooth muscle cells that are
important for vascular protection. Estrogen receptor-α (ERα) is expressed in vascular cells from …