Histamine, acting via distinct histamine H 1 , H 2 , H 3 , and H 4 receptors, regulates various
physiological and pathological processes, including pain. In the last two decades, there has …

Although numerous protocols have been developed for differentiation of neurons from a
variety of pluripotent stem cells, most have concentrated on being able to specify effectively …

Recent evidence suggests that H 2 S contributes to activation of the carotid body by hypoxia
by inhibiting K + channels. Here, we determine both the molecular identity of the K + …

Background Neural stem cells (NSCs) are considered as candidates for cell replacement
therapy in many neurological disorders. However, the propensity for their differentiation to …

Neurons differentiated from pluripotent stem cells using established neural culture conditions
often exhibit functional deficits. Recently, we have developed enhanced media which both …

NEAT1 is a highly and ubiquitously expressed long non-coding RNA (lncRNA) which serves
as an important regulator of cellular stress response. However, the physiological role of …

Cellular heterogeneity presents an important challenge to the development of cell-based
therapies where there is a fundamental requirement for predictable and reproducible outcomes…

M-channels are voltage-gated potassium channels that regulate cell excitability. They are
heterotetrameric assemblies of Kv7.2 and Kv7.3 subunits. Their opening requires the presence …

Carbon monoxide (CO) is a potent activator of large conductance, calcium-dependent
potassium (BK Ca ) channels of vascular myocytes and carotid body glomus cells or when …

The large conductance, voltage- and calcium-activated potassium channel, BK Ca , is a
known target for the gasotransmitter, carbon monoxide (CO). Activation of BK Ca by CO …