Laminins and their integrin receptors are implicated in epithelial cell differentiation and
progenitor cell maintenance. We report here that a previously unrecognized subpopulation of …

Metagenomic next-generation sequencing (mNGS) for pan-pathogen detection has been
successfully tested in proof-of-concept case studies in patients with acute illness of unknown …

Background Revised NCCN guidelines recommend that women ≤60 years with triple-negative
breast cancer (TNBC) be referred for consideration of genetic counseling. Small, …

The International Tamoxifen Pharmacogenomics Consortium was established to address
the controversy regarding cytochrome P450 2D6 (CYP2D6) status and clinical outcomes in …

Tamoxifen decreases breast cancer recurrence, mortality, and breast cancer risk in high-risk
women. Despite these proven benefits, tamoxifen use is often limited due to side effects. We …

Prevention or treatment of lung diseases caused by the failure to form, or destruction of,
existing alveoli, as observed in infants with bronchopulmonary dysplasia and adults with …

Background: Genetic association studies using case-control designs are susceptible to false-positive
and false-negative results if there are differences in genetic ancestry between …

Background Chronic Obstructive Pulmonary Disease (COPD) affects ∼16 million US adults.
Phthalates, synthetic chemicals in consumer products, may adversely impact pulmonary …

Rationale: Indoor pollutants have been associated with chronic obstructive pulmonary disease
morbidity, but it is unclear whether they contribute to disease progression. Objectives: We …

Background Indoor air quality represents a modifiable exposure to Chronic Obstructive
Pulmonary Disease (COPD) health. In a randomized controlled trial (CLEAN AIR study), air …