… Because S–S bridges are covalent bonds, the internally cross-linked N2-Bus looses
much of its extensibility, resulting in elevated cardiomyocyte passive tension (Figure 8B). …

… Titin's NH 2 -terminus is cross-linked via α-actinin, not only to actin but to a vast network
ofZ-disk-associated proteins (Figure 2), providing additional mechanical stability. In conclusion, …

Titin is a giant protein of vertebrate striated muscles (M r , ≥3000 kD). Its molecules are of
filamentous shape and span from the Z disk to the M line, thereby forming a third filament …

Aging is associated with an increased risk of cardiovascular disease and death. Here we
show that oral supplementation of the natural polyamine spermidine extends the lifespan of …

Background— To support the clinical distinction between systolic heart failure (SHF) and
diastolic heart failure (DHF), left ventricular (LV) myocardial structure and function were …

Human mutations that truncate the massive sarcomere protein titin [TTN-truncating variants (TTNtvs)]
are the most common genetic cause for dilated cardiomyopathy (DCM), a major …

Through the study of single molecules it has become possible to explain the function of
many of the complex molecular assemblies found in cells 1 , 2 , 3 , 4 , 5 . The protein titin …

Background: Advancing structural and functional maturation of stem cell–derived cardiomyocytes
remains a key challenge for applications in disease modeling, drug screening, and …

… Unlike the N2B element that has been linked to metabolism and signal transduction, the
PEVK region has so far solely been regarded as a mechanical spring. Here we have used a …

Objectives : The present study investigated whether systemic, low-grade inflammation of
metabolic risk contributed to diastolic left ventricular (LV) dysfunction and heart failure with …