The chemokine CXCL14 is a highly conserved, homeostatic chemokine that is constitutively
expressed in skin epithelia. Responsible for immune cell recruitment and maturation, as well …

Simple Summary Head and neck cancer (HNC) is the sixth most common cancer, causing
almost half a million deaths worldwide every year. The two subtypes of HNC are distinctly …

Solid tumours are innervated by nerve fibres that arise from the autonomic and sensory
peripheral nervous systems 1 , 2 , 3 , 4 – 5 . Whether the neo-innervation of tumours by pain-…

Background Human papillomavirus (HPV) is the most identifiable cause of head and neck
squamous cell cancer (HNSCC). Compared with HPV-negative HNSCC, HPV-positive …

Original research: Neoadjuvant nivolumab for patients with resectable HPV-positive and
HPV-negative squamous cell carcinomas of the head and neck in the CheckMate 358 trial - …

Patients with densely innervated tumors suffer with increased metastasis and decreased
survival as compared to those with less innervated tumors. We hypothesize that in some tumors…

PURPOSE Pembrolizumab is a humanized monoclonal antibody that blocks interaction
between programmed death receptor-1 (PD-1) and its ligands (PD-L1, PD-L2). Although …

The human papillomavirus (HPV) oncogene E6 has been shown to perform multiple functions
(p53 degradation, telomerase activation, etc.) that play a role in oncogenic transformation. …

The increasing incidence of human papillomavirus (HPV) related oropharyngeal squamous
cell carcinoma (OSSC) demands development of novel therapies. Despite presenting at a …

Background: NIVO (anti-PD-1) is approved for the treatment of several cancers including
advanced melanoma, but its efficacy in other types of skin cancer has not yet been evaluated. …