Appreciating the full spectrum of fibroblast heterogeneity in pancreatic ductal adenocarcinoma
is crucial to developing therapies that specifically target tumor-promoting CAFs. This work …

This study reports the 15-year survivorship of 112 consecutive Total Condylar knee arthroplasties
that have been followed since 1974. Two endpoints were chosen for survivorship:(1) …

Potts Hamiltonian models of protein sequence co-variation are statistical models constructed
from the pair correlations observed in a multiple sequence alignment (MSA) of a protein …

A major rate-limiting step in developing more effective immunotherapies for GBM is our
inadequate understanding of the cellular complexity and the molecular heterogeneity of immune …

Patients with systemic lupus erythematosus (SLE) display a complex blood transcriptome
whose cellular origin is poorly resolved. Using single-cell RNA sequencing, we profiled ~…

INTRODUCTION Cross-linking of high-affinity, allergen-specific immunoglobulin E (IgE) on
mast cells results in anaphylaxis, a potentially life-threatening allergic reaction. The cellular …

Insulin resistance is a pathological state often associated with obesity, representing a major
risk factor for type 2 diabetes. Limited mechanism-based strategies exist to alleviate insulin …

: Contemporary knee designs differ considerably in the conformity that exists between the
articulating surfaces of the femoral and tibial components. The thickness of the polyethylene …

Endometriosis is characterized by the growth of endometrial-like tissue outside the uterus. It
affects many women during their reproductive age, causing years of pelvic pain and …

Background Cancer of unknown primary (CUP), representing approximately 3-5% of all
malignancies, is defined as metastatic cancer where a primary site of origin cannot be found …