Filaggrin mutations associated with skin and allergic diseases
AD Irvine, WHI McLean… - New England Journal of …, 2011 - Mass Medical Soc
Mutations in the filaggrin gene are associated with a broad range of skin and allergic
diseases. The biology of this molecule and the role of mutations in its altered function offer …
diseases. The biology of this molecule and the role of mutations in its altered function offer …
Filaggrin in the frontline: role in skin barrier function and disease
…, C Sutherland, AD Irvine, WHI McLean - Journal of cell …, 2009 - journals.biologists.com
Recently, loss-of-function mutations in FLG, the human gene encoding profilaggrin and
filaggrin, have been identified as the cause of the common skin condition ichthyosis vulgaris (…
filaggrin, have been identified as the cause of the common skin condition ichthyosis vulgaris (…
Filaggrin in atopic dermatitis
GM O'Regan, A Sandilands, WHI McLean… - Journal of Allergy and …, 2008 - Elsevier
The recent identification of loss-of-function mutations in the structural protein filaggrin as a
widely replicated major risk factor for eczema sheds new light on disease mechanisms in …
widely replicated major risk factor for eczema sheds new light on disease mechanisms in …
Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis
Atopic disease, including atopic dermatitis (eczema), allergy and asthma, has increased in
frequency in recent decades 1 and now affects ∼20% of the population in the developed …
frequency in recent decades 1 and now affects ∼20% of the population in the developed …
Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris
…, RB Presland, P Fleckman, WHI McLean - Nature …, 2006 - nature.com
Ichthyosis vulgaris (OMIM 146700) is the most common inherited disorder of keratinization
and one of the most frequent single-gene disorders in humans. The most widely cited …
and one of the most frequent single-gene disorders in humans. The most widely cited …
[HTML][HTML] Genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1
…, L Mallbris, HS Markus, CG Mathew, WHI McLean… - Nature …, 2010 - ncbi.nlm.nih.gov
(WTCCC2) consortia is provided in the Supplementary Note online. Author Contributions FC,
ADB, CEMG, J. Kere., A. Reis, JNB and RCT oversaw cohort collection for both the …
ADB, CEMG, J. Kere., A. Reis, JNB and RCT oversaw cohort collection for both the …
[HTML][HTML] Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention
Background Atopic dermatitis (atopic eczema) is a chronic inflammatory skin disease that
has reached epidemic proportions in children worldwide and is increasing in prevalence. …
has reached epidemic proportions in children worldwide and is increasing in prevalence. …
Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema
We recently reported two common filaggrin (FLG) null mutations that cause ichthyosis vulgaris
1 and predispose to eczema and secondary allergic diseases 2 . We show here that these …
1 and predispose to eczema and secondary allergic diseases 2 . We show here that these …
Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations
…, H Behrendt, J Ring, MM Nothen, WHI McLean… - Journal of Allergy and …, 2006 - Elsevier
BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disease with a strong
genetic background. One of the characteristic features of AD and causative factor for the …
genetic background. One of the characteristic features of AD and causative factor for the …
[HTML][HTML] One remarkable molecule: filaggrin
SJ Brown, WHI McLean - Journal of Investigative Dermatology, 2012 - Elsevier
The discovery, in 2006, that loss-of-function mutations in the filaggrin (FLG) gene are the
cause of ichthyosis vulgaris—the most common disorder of keratinization—and also a strong …
cause of ichthyosis vulgaris—the most common disorder of keratinization—and also a strong …