The specification and proper arrangements of new cell types during tissue differentiation
require the coordinated regulation of gene expression and precise interactions between …

Epithelial cell-cell junctions, organized by adhesion proteins and the underlying actin
cytoskeleton, are considered to be stable structures maintaining the structural integrity of tissues. …

Spatial and functional organization of cells in tissues is determined by cell-cell adhesion,
thought to be initiated through trans-interactions between extracellular domains of the cadherin …

INTRODUCTION Cadherins are an ancient class of transmembrane proteins that are
essential for the formation of multicellular tissues in metazoans. Cadherins link intercellular …

Mechanical strain regulates the development, organization, and function of multicellular
tissues, but mechanisms linking mechanical strain and cell-cell junction proteins to cellular …

Cell-cell adhesion plays critical roles in establishing and maintaining tissue architecture and
function (1, 2). In these roles, cell-cell adhesion must be adaptable and (depending on the …

… Work from the Nelson laboratory is supported by a grant from the NIH (GM 35527); Andrea
Hartsock is additionally supported under the NIH Cell and Molecular Biology Training …

… James Nelson… with cadherin and actin (Weis and Nelson 2006). An additional candidate
protein is … Work from the Nelson laboratory is supported by the NIH (GM35527), and a HHMI …

Cell polarity is the ultimate reflection of complex mechanisms that establish and maintain
functionally specialized domains in the plasma membrane and cytoplasm. The spatial …

Polarized epithelial cells play fundamental roles in the ontogeny and function of a variety of
tissues and organs in mammals. The morphogenesis of a sheet of polarized epithelial cells (…