In Silico Design and Enzymatic Synthesis of Functional RNA Nanoparticles
KA Afonin, WK Kasprzak, E Bindewald… - Accounts of chemical …, 2014 - ACS Publications
Conspectus The use of RNAs as scaffolds for biomedical applications has several advantages
compared with other existing nanomaterials. These include (i) programmability, (ii) …
compared with other existing nanomaterials. These include (i) programmability, (ii) …
Multifunctional RNA nanoparticles
…, M Viard, AY Koyfman, AN Martins, WK Kasprzak… - Nano …, 2014 - ACS Publications
Our recent advancements in RNA nanotechnology introduced novel nanoscaffolds (nanorings);
however, the potential of their use for biomedical applications was never fully revealed. …
however, the potential of their use for biomedical applications was never fully revealed. …
[HTML][HTML] Ribosomal frameshifting in the CCR5 mRNA is regulated by miRNAs and the NMD pathway
… were performed as previously described 28 with the following modifications: Streptavidin
agarose beads were pre-washed as described in 500 µl aliquots and stored for up to a week at …
agarose beads were pre-washed as described in 500 µl aliquots and stored for up to a week at …
HLA class I signal peptide polymorphism determines the level of CD94/NKG2–HLA-E-mediated regulation of effector cell responses
…, M Quastel, M Beiersdorfer, WK Kasprzak… - Nature …, 2023 - nature.com
Human leukocyte antigen (HLA)-E binds epitopes derived from HLA-A, HLA-B, HLA-C and
HLA-G signal peptides (SPs) and serves as a ligand for CD94/NKG2A and CD94/NKG2C …
HLA-G signal peptides (SPs) and serves as a ligand for CD94/NKG2A and CD94/NKG2C …
Triggering of RNA Interference with RNA–RNA, RNA–DNA, and DNA–RNA Nanoparticles
…, J Hofmann, A Vrzak, M Kireeva, WK Kasprzak… - ACS …, 2015 - ACS Publications
Control over cellular delivery of different functionalities and their synchronized activation is
a challenging task. We report several RNA and RNA/DNA-based nanoparticles designed to …
a challenging task. We report several RNA and RNA/DNA-based nanoparticles designed to …
[HTML][HTML] Inhibition of vemurafenib-resistant melanoma by interference with pre-mRNA splicing
… Tumour growth was assessed twice a week using a digital caliper. Tumour volume was
calculated according to the formula d × D, where d and D are the shortest and the longest …
calculated according to the formula d × D, where d and D are the shortest and the longest …
Functionally-interdependent shape-switching nanoparticles with controllable properties
…, A Ivanina, E Bindewald, WK Kasprzak… - Nucleic acids …, 2017 - academic.oup.com
We introduce a new concept that utilizes cognate nucleic acid nanoparticles which are fully
complementary and functionally-interdependent to each other. In the described approach, …
complementary and functionally-interdependent to each other. In the described approach, …
RNA2Drawer: geometrically strict drawing of nucleic acid structures with graphical structure editing and highlighting of complementary subsequences
PZ Johnson, WK Kasprzak, BA Shapiro, AE Simon - RNA biology, 2019 - Taylor & Francis
RNA structure prediction programs remain imperfect and many substructures are still
identified by manual exploration, which is most efficiently conducted within an RNA structure …
identified by manual exploration, which is most efficiently conducted within an RNA structure …
[PDF][PDF] Structural differences between Pri-miRNA paralogs promote alternative drosha cleavage and expand target repertoires
X Bofill-De Ros, WK Kasprzak, Y Bhandari, L Fan… - Cell reports, 2019 - cell.com
MicroRNA (miRNA) processing begins with Drosha cleavage, the fidelity of which is critical
for downstream processing and mature miRNA target specificity. To understand how pri-…
for downstream processing and mature miRNA target specificity. To understand how pri-…
Co-transcriptional production of RNA–DNA hybrids for simultaneous release of multiple split functionalities
…, CL Case, AE Maciag, WK Kasprzak… - Nucleic acids …, 2014 - academic.oup.com
Control over the simultaneous delivery of different functionalities and their synchronized
intracellular activation can greatly benefit the fields of RNA and DNA biomedical …
intracellular activation can greatly benefit the fields of RNA and DNA biomedical …