Notch receptors influence cellular behavior by participating in a seemingly simple signaling
pathway, but outcomes produced by Notch signaling are remarkably varied depending on …

… (42–44; JC Aster and WS Pear, unpublished) and because Notch2-4 can rescue T cell
development in the absence of Notch1 signals (I. Maillard and WS Pear, unpublished). In addition …

… Conversely, Notch signaling promotes growth arrest and/or apoptosis of some avian and
murine B cell lines60,61 (He Y, Pear WS, in preparation). Thus, Notch signaling might also …

The generation of high-titer, helper-free retroviruses by transient transfection has been
achieved by using the highly transfectable 293T cell line into which are stably introduced …

… ICN1 localizes to the nucleus and is constitutively active (Pear et al., 1996; Aster et al.,
1997). … seemingly unafwere incubated with either the Notch-specific anti-Tc antibody (Pear …

… thank Alan Diehl and Charles Vinson for providing reagents, and Gerd Blobel, Tom Kadesch,
David Levens, Steve McMahon, Gary Koretzky, Craig Thompson, and members of the Pear …

… envelope gene was absent from the malignant cells (Pear, W., unpublished data). Second, …
, only one has developed a T cell malignancy (Pear W., and M. Scott, unpublished data). …

Expression of the 210-kD bcr/abl fusion oncoprotein can cause a chronic myelogenous
leukemia (CML)-like disease in mice receiving bone marrow cells transduced by bcr/abl-…

Hematopoietic stem cells give rise to progeny that either self-renew in an undifferentiated
state or lose self-renewal capabilities and commit to lymphoid or myeloid lineages. Here we …

Although regeneration through the reprogramming of one cell lineage to another occurs in
fish and amphibians, it has not been observed in mammals. We discovered in the mouse that …