Across the animal kingdom, gastrulation represents a key developmental event during which
embryonic pluripotent cells diversify into lineage-specific precursors that will generate the …

Reconstruction of the molecular pathways controlling organ development has been hampered
by a lack of methods to resolve embryonic progenitor cells. Here we describe a strategy to …

In mammals, specification of the three major germ layers occurs during gastrulation, when
cells ingressing through the primitive streak differentiate into the precursor cells of major …

Background Neuroendocrine tumours (NET) of the appendix are rare histopathological
neoplasms detected following operation for appendicitis in childhood. The role (if any) for radical …

During gastrulation, cell types from all three germ layers are specified and the basic body
plan is established 1 . However, molecular analysis of this key developmental stage has been …

Capturing where and how multipotency is lost is crucial to understand how blood formation
is controlled. Blood lineage specification is currently thought to occur downstream of …

… Using this wide (+W) gate (MFI = 150–7,000), CD27+W cells were isolated and transplanted
into irradiated recipients. High-level, long-term multilineage in vivo repopulation by the …

Objectives To identify sub-populations of intestinal preproglucagon-expressing (PPG) cells
producing Glucagon-like Peptide-1, and their associated expression profiles of sensory …

Background The anatomical defect in congenital diaphragmatic hernia (CDH) can usually
be closed primarily but prosthetic patch repair may be required in newborns with a deficient …

… Edri, a Wellcome Trust Clinical PhD Fellowship (grant numbers 103392/Z/13/Z and
103392/Z/13/A) to W. Jawaid and a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust …