User profiles for W. Le Clec’h

Winka Le Clec'h

Texas Biomedical Research Institute
Verified email at txbiomed.org
Cited by 690

[HTML][HTML] Cannibalism and Predation as Paths for Horizontal Passage of Wolbachia between Terrestrial Isopods

W Le Clec'h, FD Chevalier, L Genty, J Bertaux… - PloS one, 2013 - journals.plos.org
… Winka Le Clech’s work was supported by a grant from Région Poitou-charentes. The
funders had no role in study design, data collection and analysis, decision to publish, or …

Snails, microbiomes, and schistosomes: a three-way interaction?

W Le Clec'h, S Nordmeyer, TJC Anderson… - Trends in …, 2022 - cell.com
Aquatic snails, the intermediate hosts of schistosomes, harbor a diverse unexplored
microbiome. We speculate that this may play a critical role in host–parasite interactions. We …

Genetic crosses and linkage mapping in schistosome parasites

TJC Anderson, PT LoVerde, W Le Clec'h… - Trends in …, 2018 - cell.com
Linkage mapping – utilizing experimental genetic crosses to examine cosegregation of
phenotypic traits with genetic markers – is now 100 years old. Schistosome parasites are …

Ancient hybridization and adaptive introgression of an invadolysin gene in schistosome parasites

RN Platt, M McDew-White, W Le Clec'h… - Molecular Biology …, 2019 - academic.oup.com
… Winka Le Clech , Winka Le Clech … (Illumina 2500) to generate genome-wide sequence
data following methods described in Le Clech et al. (2018). The exome capture probe set (…

Genetic analysis of praziquantel response in schistosome parasites implicates a transient receptor potential channel

W Le Clec'h, FD Chevalier, ACA Mattos… - Science translational …, 2021 - science.org
… A pair of manuscripts by Park et al. and Le Clech et al. identified a Schistosoma mansoni …
Le Clech et al. used a genome-wide association screen and marker-assisted selection to …

[HTML][HTML] Characterization of hemolymph phenoloxidase activity in two Biomphalaria snail species and impact of Schistosoma mansoni infection

W Le Clec'h, TJC Anderson, FD Chevalier - Parasites & vectors, 2016 - Springer
… We detected PO activity after 4 h using the L-DOPA substrate, which can be metabolized by
all three types of enzyme, on the same hemolymph samples. Test wells and inhibition control …

[HTML][HTML] High Virulence of Wolbachia after Host Switching: When Autophagy Hurts

W Le Clec'h, C Braquart-Varnier, M Raimond… - PLoS …, 2012 - journals.plos.org
Wolbachia are widespread endosymbionts found in a large variety of arthropods. While these
bacteria are generally transmitted vertically and exhibit weak virulence in their native hosts…

[HTML][HTML] Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment

FD Chevalier, W Le Clec'h, M McDew-White… - PLoS …, 2019 - journals.plos.org
… We aligned sequences as described in Le Clech et al. [64]. Briefly, we aligned data against
… After 2.5 h of incubation at 37C, the reaction was stopped and DNA was extracted three times…

[HTML][HTML] Independent origins of loss-of-function mutations conferring oxamniquine resistance in a Brazilian schistosome population

FD Chevalier, W Le Clec'h, N Eng, AR Rugel… - International journal for …, 2016 - Elsevier
Molecular surveillance provides a powerful approach to monitoring the resistance status of
parasite populations in the field and for understanding resistance evolution. Oxamniquine …

Genomic analysis of a parasite invasion: Colonization of the Americas by the blood fluke Schistosoma mansoni

RN Platt, W Le Clec'h, FD Chevalier… - Molecular …, 2022 - Wiley Online Library
… We examined genome regions that were targeted by the Le Clec'h et al. (2018) probe set
for these calculations; nontarget regions (ie, nonexomic) were ignored because most samples …