Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is characterized
by the degeneration of both upper and lower motor neurons, which leads to muscle …

Several recent breakthroughs have provided notable insights into the pathogenesis of
amyotrophic lateral sclerosis (ALS), with some even shifting our thinking about this …

Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic
lateral sclerosis (ALS) are characterised by the appearance of reactive microglial and …

Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple
sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 …

Hypoxia stimulates angiogenesis through the binding of hypoxia-inducible factors to the
hypoxia-response element in the vascular endothelial growth factor (Vegf) promotor. Here, we …

<p id="p001">The prior diagnosis of fatal astrocytoma in a 60-year-old man with Crohn's
disease treated with natalizumab, a monoclonal antibody against α₄ integrins, was …

Amyotrophic lateral sclerosis (ALS) is an incurable degenerative disorder of motoneurons.
We recently reported that reduced expression of Vegfa causes ALS-like motoneuron …

Neurotrophin treatment has so far failed to prolong the survival of individuals affected with
amyotrophic lateral sclerosis (ALS), an incurable motoneuron degenerative disorder. Here we …

C9orf72 mutations are the most common cause of amyotrophic lateral sclerosis (ALS) and
frontotemporal dementia (FTD). Dipeptide repeat proteins (DPRs) produced by …

Background Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD)
are extremes of a clinically, pathologically, and genetically overlapping disease spectrum…