[HTML][HTML] Phosphodiesterase 11A (PDE11A), enriched in ventral hippocampus neurons, is required for consolidation of social but not nonsocial memories in mice
S Hegde, WR Capell, BA Ibrahim, J Klett… - …, 2016 - nature.com
The capacity to form long-lasting social memories is critical to our health and survival. cAMP
signaling in the ventral hippocampal formation (VHIPP) appears to be required for social …
signaling in the ventral hippocampal formation (VHIPP) appears to be required for social …
[HTML][HTML] PDE11A negatively regulates lithium responsivity
G Pathak, MJ Agostino, K Bishara, WR Capell… - Molecular …, 2017 - nature.com
… (WR Capell and MP Kelly, personal observations). Interestingly, protein kinase C is expressed
at much higher levels in DHIPP vs VHIPP 75 and is predicted to phosphorylate PDE11A4 …
at much higher levels in DHIPP vs VHIPP 75 and is predicted to phosphorylate PDE11A4 …
Conserved age‐related increases in hippocampal PDE11A4 cause unexpected proteinopathies and cognitive decline of social associative memories
K Pilarzyk, L Porcher, WR Capell, SD Burbano… - Aging …, 2022 - Wiley Online Library
In humans, associative memories are more susceptible to age‐related cognitive decline (ARCD)
than are recognition memories. Reduced cAMP/cGMP signaling in the hippocampus …
than are recognition memories. Reduced cAMP/cGMP signaling in the hippocampus …
Biologic that disrupts PDE11A4 homodimerization in hippocampus CA1 reverses age-related cognitive decline of social memories in mice
K Pilarzyk, WR Capell, L Porcher, A Rips-Goodwin… - Neurobiology of …, 2023 - Elsevier
Age-related abnormalities in phosphodiesterase 11A (PDE11A), which degrades 3′,5′-cAMP/cGMP
and is enriched in the ventral hippocampus (VHIPP), drive age-related cognitive …
and is enriched in the ventral hippocampus (VHIPP), drive age-related cognitive …
The Laragia language
A Capell - Pacific Linguistics. Series A. Occasional Papers, 1984 - search.proquest.com
… Capell 1. INTRODUCTION Laragia was the language of the district where Darwin, the …
Capell 55 THE LARAG IA LANGUAGE 56 A. CAPEll The following phonemes are to be recognised…
Capell 55 THE LARAG IA LANGUAGE 56 A. CAPEll The following phonemes are to be recognised…
Unexpected proteinopathies in hippocampal PDE11A4 promote age-related cognitive decline of social associative memories
K Pilarzyk, L Porcher, WR Capell, SD Burbano, J Davis… - bioRxiv, 2022 - biorxiv.org
In humans, associative memories are more susceptible to age-related cognitive decline (ARCD)
than are recognition memories. Reduced cAMP/cGMP signaling in the hippocampus …
than are recognition memories. Reduced cAMP/cGMP signaling in the hippocampus …
[HTML][HTML] Rivaroxaban in peripheral artery disease after revascularization
Background Patients with peripheral artery disease who have undergone lower-extremity
revascularization are at high risk for major adverse limb and cardiovascular events. The …
revascularization are at high risk for major adverse limb and cardiovascular events. The …
[HTML][HTML] Maturation and pro-peptide cleavage of β-secretase
A Capell, H Steiner, M Willem, H Kaiser… - Journal of Biological …, 2000 - ASBMB
Amyloid β-peptide is generated by two sequential proteolytic cleavages mediated by β-secretase
(BACE) and γ-secretase. BACE was recently identified as a membrane-associated …
(BACE) and γ-secretase. BACE was recently identified as a membrane-associated …
Rationale and design for the Vascular Outcomes study of ASA along with rivaroxaban in endovascular or surgical limb revascularization for peripheral artery disease …
… Capell MD a b , Marc P. Bonaca MD, MPH c , Mark R. Nehler MD a d , Edmond Chen MD e ,
John M. … Dr Capell and Dr Nehler have no conflicts. … Norgren, WR Hiatt, JA Dormandy, et al. …
John M. … Dr Capell and Dr Nehler have no conflicts. … Norgren, WR Hiatt, JA Dormandy, et al. …
A structured review of antithrombotic therapy in peripheral artery disease with a focus on revascularization: a TASC (InterSociety Consensus for the Management of …
Peripheral artery disease affects >200 million people worldwide and is associated with
significant limb and cardiovascular morbidity and mortality. Limb revascularization is …
significant limb and cardiovascular morbidity and mortality. Limb revascularization is …