PYRIN-containing Apaf-1-like proteins (PYPAFs) are a recently identified family of proteins
thought to function in apoptotic and inflammatory signaling pathways. PYPAF1 and PYPAF7 …

PCSK9 (proprotein convertase subtilisin/kexin 9) is a secreted serine protease that regulates
cholesterol homoeostasis by inducing post-translational degradation of hepatic LDL-R […

BCL10 belongs to the caspase recruitment domain (CARD) family of proteins that regulate
apoptosis and NF-κB signaling pathways. Analysis of BCL10-deficient mice has revealed that …

The With-No-Lysine (K) (WNK) kinases play a critical role in blood pressure regulation and
body fluid and electrolyte homeostasis. Herein, we introduce the first orally bioavailable pan-…

The CED4/Apaf-1 family of proteins functions as critical regulators of apoptosis and NF-κB
signaling pathways. A novel human member of this family, called CARD12, was identified that …

Fibroblast growth factor (FGF) 21 is a member of the FGF family of proteins. The biological
activity of FGF21 was first shown to induce insulin-independent glucose uptake in adipocytes …

The With-No-Lysine (K)(WNK) kinases play a critical role in blood pressure regulation and
body fluid and electrolyte homeostasis. Herein, we introduce the first orally bioavailable pan-…

The study of ion channel-mediated changes in membrane potential using the conventional
bisoxonol fluorescent dye DiBAC 4 (3) has several limitations, including a slow onset of …

The observed structure–activity relationship of three distinct ATP noncompetitive With-No-Lysine
(WNK) kinase inhibitor series, together with a crystal structure of a previously disclosed …

… Nagle and Lisa Dirocco for assistance with BAC subcloning, Waan-Jeng Nir for help with
cDNA selection, and Line Laroche for technical assistance. … Huang …