Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease. Tumors are
poorly immunogenic and immunosuppressive, preventing T cell activation in the tumor …

Purpose: Adipocytes represent one of the most abundant constituents of the mammary gland.
They are essential for mammary tumor growth and survival. Metabolically, one of the more …

Thyroid dysfunction is a global health concern, causing defects including neurodevelopmental
disorders, dwarfism and cardiac arrhythmia. Here, we show that the potassium channel …

For the greater part of the last century, basic science research has been limited to in vitro
studies of cellular processes and ex vivo tissue examination from suitable animal models of …

Background Trypanosoma cruzi, the causative agent of Chagas disease, has high affinity
for lipoproteins and adipose tissue. Infection results in myocarditis, fat loss and alterations in …

The KCNQ1 α subunit and the KCNE2 β subunit form a potassium channel in thyroid epithelial
cells. Genetic disruption of KCNQ1-KCNE2 causes hypothyroidism in mice, resulting in …

Our laboratory has developed a novel delivery platform using an attenuated non-toxic and
non-pathogenic bacterium Listeria monocytogenes that infects tumor cells and selectively …

Chagas disease, caused by infection with Trypanosoma cruzi, is an important cause of
cardiovascular disease. It is increasingly clear that parasite-derived prostaglandins potently …

Imaging devices for small animals have emerged in the past 10 years as extraordinarily useful
tools in translational research and drug development. The Food and Drug Administration …

Background Chagas disease, resulting from infection with the parasite Trypanosoma cruzi (T.
cruzi), is a major cause of cardiomyopathy in Latin America. Drug therapy for acute and …