Parkinson’s disease-associated kinase LRRK2 has been linked to IFN type II (IFN-γ) response
in infections and to dopaminergic neuronal loss. However, whether and how LRRK2 …

During neuronal degenerative diseases, neuronal microcircuits undergo severe structural
alterations, leading to remodeling of synaptic connectivity. The functional consequences of …

Electrical (e-) stimulation is explored in schemes to rescue the vision of blind people, eg
those affected by Retinitis Pigmentosa (RP). We e-activated subretinally the surviving …

The vertebrate retina harbors rod and cone photoreceptors. Human vision critically depends
on cone photoreceptor function. In the phototransduction cascade, cGMP activates distinct …

10.7554/eLife.46188.001 The devastating effects and incurable nature of hereditary and
sporadic retinal diseases such as Stargardt disease, age-related macular degeneration or …

Cone photoreceptor cell death in inherited retinal diseases, such as Retinitis Pigmentosa (RP),
leads to the loss of high acuity and color vision and, ultimately to blindness. In RP, a vast …

Background: The electroretinogram (ERG) is an essential diagnostic tool for visual function,
both in clinical and research settings. Here, we establish an advanced in vitro approach to …

The inspection of retinal fundus pictures taken by a fundus camera is one of the key
procedures for diagnosing a wide range of diseases like diabetic retinopathy, hypertension or …

… Wadood Haq conceived the idea of a nature-inspired biomimetic stimulation paradigm and
… Sunetra Basavaraju, Achim Speck, and Wadood Haq prepared the figures and worked on the …

Background: The electrical stimulation (stim) of retinal neurons enables blind patients to
experience limited artificial vision. A rapid response outage of the stimulated ganglion cells (GCs…